Cellular senescence is a well-established driver of aging and age-related diseases. There
are many challenges to mapping senescent cells in tissues such as the absence of specific …

Most age-related neurodegenerative diseases remain incurable owing to an incomplete
understanding of the disease mechanisms. Several environmental and genetic factors …

The contribution of mitochondria to the metabolic function of hypoxic NP cells has been
overlooked. We have shown that NP cells contain networked mitochondria and that …

Modulation of the immune response to initiate and halt the inflammatory process occurs both
at the site of injury as well as systemically. Due to the evolving role of cellular metabolism in …

Self-renewal and differentiation of skeletal stem and progenitor cells (SSPCs) are tightly
regulated processes, with SSPC dysregulation leading to progressive bone disease. While …

Background Embryos are regeneration and wound healing masters. They rapidly close
wounds and scarlessly remodel and regenerate injured tissue. Regeneration has been …

The cell-cell interactions are fundamental mechanisms of differentiating embryonic tissues. 1
We aimed to model human embryonic development in stem-cell-derived organoids. We …

The development of brain in vitro models requires the application of novel biocompatible
materials and biopolymers as scaffolds for controllable and effective cell growth and …

Regeneration, regrowing lost and injured body parts, is an ability that generally declines
with age or developmental transitions (ie metamorphosis, sexual maturation). Regeneration …

One of the enduring debates in regeneration biology is the degree to which regeneration
mirrors development. Recent technical advances, such as single-cell transcriptomics and …