Antibacterial drug discovery in the resistance era

ED Brown, GD Wright - Nature, 2016 - nature.com
The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians,
researchers, policymakers, politicians and the public at large. The evolution and widespread …

Wall teichoic acids of gram-positive bacteria

S Brown, JP Santa Maria Jr… - Annual review of …, 2013 - annualreviews.org
The peptidoglycan layers of many gram-positive bacteria are densely functionalized with
anionic glycopolymers known as wall teichoic acids (WTAs). These polymers play crucial …

A new antibiotic kills pathogens without detectable resistance

LL Ling, T Schneider, AJ Peoples, AL Spoering… - Nature, 2015 - nature.com
Antibiotic resistance is spreading faster than the introduction of new compounds into clinical
practice, causing a public health crisis. Most antibiotics were produced by screening soil …

Cell wall structure and function in lactic acid bacteria

MP Chapot-Chartier, S Kulakauskas - Microbial cell factories, 2014 - Springer
The cell wall of Gram-positive bacteria is a complex assemblage of glycopolymers and
proteins. It consists of a thick peptidoglycan sacculus that surrounds the cytoplasmic …

Envelope structures of Gram-positive bacteria

M Rajagopal, S Walker - Protein and sugar export and assembly in Gram …, 2017 - Springer
Gram-positive organisms, including the pathogens Staphylococcus aureus, Streptococcus
pneumoniae, and Enterococcus faecalis, have dynamic cell envelopes that mediate …

Reduced Vancomycin Susceptibility in Staphylococcus aureus, Including Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Strains …

BP Howden, JK Davies, PDR Johnson… - Clinical microbiology …, 2010 - Am Soc Microbiol
The emergence of vancomycin-intermediate Staphylococcus aureus (VISA) and
heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) over the past …

Teichoic acids and related cell-wall glycopolymers in Gram-positive physiology and host interactions

C Weidenmaier, A Peschel - Nature Reviews Microbiology, 2008 - nature.com
Abstract Abstract| Most Gram-positive bacteria incorporate membrane-or peptidoglycan-
attached carbohydrate-based polymers into their cell envelopes. Such cell-wall …

[图书][B] Practical handbook of microbiology

LH Green, E Goldman - 2021 - books.google.com
Practical Handbook of Microbiology, 4th edition provides basic, clear and concise
knowledge and practical information about working with microorganisms. Useful to anyone …

[HTML][HTML] Wall teichoic acid function, biosynthesis, and inhibition

JG Swoboda, J Campbell, TC Meredith… - … : a European journal of …, 2010 - ncbi.nlm.nih.gov
One of the major differences between Gram-negative and Gram-positive organisms is the
presence or absence of an outer membrane (Figure 1). In Gram-negative organisms, the …

β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium

JF Fisher, S Mobashery - Chemical reviews, 2020 - ACS Publications
The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …