The diverse biological properties of the chemically inert noble gases

DA Winkler, A Thornton, G Farjot, I Katz - Pharmacology & therapeutics, 2016 - Elsevier
The noble gases represent an intriguing scientific paradox. They are extremely inert
chemically but display a remarkable spectrum of clinically useful biological properties …

[HTML][HTML] Neuroprotection by the noble gases argon and xenon as treatments for acquired brain injury: a preclinical systematic review and meta-analysis

M Liang, F Ahmad, R Dickinson - British Journal of Anaesthesia, 2022 - Elsevier
Background The noble gases argon and xenon are potential novel neuroprotective
treatments for acquired brain injuries. Xenon has already undergone early-stage clinical …

The cellular mechanisms associated with the anesthetic and neuroprotective properties of xenon: a systematic review of the preclinical literature

S McGuigan, DJ Marie, LJ O'Bryan, FJ Flores… - Frontiers in …, 2023 - frontiersin.org
Introduction Xenon exhibits significant neuroprotection against a wide range of neurological
insults in animal models. However, clinical evidence that xenon improves outcomes in …

The neuroprotective effect and possible therapeutic application of xenon in neurological diseases

M Zhang, Y Cui, Y Cheng, Q Wang… - Journal of Neuroscience …, 2021 - Wiley Online Library
Xenon is an inert gas with stable chemical properties which is used as an anesthetic. Recent
in vitro and in vivo findings indicate that xenon also elicits an excellent neuroprotective effect …

The efficacy of noble gases in the attenuation of ischemia reperfusion injury: a systematic review and meta-analyses

J De Deken, S Rex, D Monbaliu, J Pirenne… - Critical Care …, 2016 - journals.lww.com
Objective: Noble gases have been attributed to organ protective effects in ischemia
reperfusion injury in a variety of medical conditions, including cerebral and cardiac …

Xenon exerts anti-seizure and neuroprotective effects in kainic acid-induced status epilepticus and neonatal hypoxia-induced seizure

Y Zhang, M Zhang, S Liu, W Zhu, J Yu, Y Cui… - Experimental …, 2019 - Elsevier
Xenon is an inhalation anesthetic with a favorable safety profile, and previous studies have
demonstrated its neuroprotective efficacy. However, whether xenon plays a role in the …

Delayed xenon post-conditioning mitigates spinal cord ischemia/reperfusion injury in rabbits by regulating microglial activation and inflammatory factors

Y Yang, Y Wang, J Lu, L Tian, M Jin… - Neural Regeneration …, 2018 - journals.lww.com
The neuroprotective effect against spinal cord ischemia/reperfusion injury in rats exerted by
delayed xenon post-conditioning is stronger than that produced by immediate xenon post …

Xenon Exerts Neuroprotective Effects on Kainic Acid-Induced Acute Generalized Seizures in Rats via Increased Autophagy

W Zhu, J Zhu, S Zhao, J Li, D Hou, Y Zhang… - Frontiers in Cellular …, 2020 - frontiersin.org
Xenon has been shown to have neuroprotective effects and is clinically used as a favorable
safe inhalation anesthetic. We previously confirmed the neuroprotective effects of xenon …

Mode-dependent effect of xenon inhalation on kainic acid-induced status epilepticus in rats

Y Zhang, M Zhang, J Yu, W Zhu, Q Wang… - Frontiers in Cellular …, 2019 - frontiersin.org
Previous studies have reported the possible neuroprotective effects of xenon treatment. The
purpose of this study was to define the range of effective xenon ratio, most effective xenon …

Attenuated iron stress and oxidative stress may participate in anti-seizure and neuroprotective roles of xenon in pentylenetetrazole-induced epileptogenesis

M Zhang, Y Cheng, Y Zhai, Y Yuan, H Hu… - Frontiers in Cellular …, 2022 - frontiersin.org
The previous studies have demonstrated the excellent neuroprotective effects of xenon. In
this study, we verified the anti-seizure and neuroprotective roles of xenon in epileptogenesis …