Attention is critical to high-level cognition and attention deficits are a hallmark of neurologic
and neuropsychiatric disorders. Although years of research indicates that distinct …

The brain continuously adapts its processing machinery to behavioural demands. To
achieve this, it rapidly modulates the operating mode of cortical circuits, controlling the way …

Noradrenergic and cholinergic systems are among the most vulnerable brain systems in
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …

The nucleus basalis of the basal forebrain is an essential component of the
neuromodulatory system controlling the behavioral state of an animal and it is thought to be …

Neural slowing is commonly noted in older adults, with consequences for sensory, motor,
and cognitive domains. One of the deleterious effects of neural slowing is impairment of …

The common marmoset (Callithrix jacchus) has been valuable as a primate model in
biomedical research. Interest in this species has grown recently, in part due to the successful …

Acetylcholine is a ubiquitous cortical neuromodulator implicated in cognition. In order to
understand the potential for acetylcholine to play a role in visual attention, we studied …

The basal forebrain cholinergic system (BFCS) has long been implicated in age-related
cognitive changes and the pathophysiology of Alzheimer's disease (AD). Limitations of …

Although cholinergic innervation of the cortex by the nucleus basalis (NB) is known to
modulate cortical neuronal responses and instruct cortical plasticity, little is known about the …

Humans are diurnal primates with high visual acuity at the center of gaze. Although primates
share many similarities in the organization of their visual centers with other mammals, and …