[HTML][HTML] Computational modeling of cardiac growth and remodeling in pressure overloaded hearts—Linking microstructure to organ phenotype

JA Niestrawska, CM Augustin, G Plank - Acta biomaterialia, 2020 - Elsevier
Cardiac growth and remodeling (G&R) refers to structural changes in myocardial tissue in
response to chronic alterations in loading conditions. One such condition is pressure …

[HTML][HTML] Cardiac multi-scale investigation of the right and left ventricle ex vivo: a review

H Dejea, A Bonnin, AC Cook… - … diagnosis and therapy, 2020 - ncbi.nlm.nih.gov
The heart is a complex multi-scale system composed of components integrated at the
subcellular, cellular, tissue and organ levels. The myocytes, the contractile elements of the …

[HTML][HTML] Patient-specific modeling for left ventricular mechanics using data-driven boundary energies

L Asner, M Hadjicharalambous, R Chabiniok… - Computer Methods in …, 2017 - Elsevier
Supported by the wide range of available medical data available, cardiac biomechanical
modeling has exhibited significant potential to improve our understanding of heart function …

Impact of aortic stenosis on myofiber stress: translational application of left ventricle-aortic coupling simulation

AD Wisneski, Y Wang, T Deuse, AC Hill… - Frontiers in …, 2020 - frontiersin.org
The severity of aortic stenosis (AS) has traditionally been graded by measuring
hemodynamic parameters of transvalvular pressure gradient, ejection jet velocity, or …

In vivo estimation of normal left ventricular stiffness and contractility based on routine cine MR acquisition

GK Rumindo, J Ohayon, P Croisille… - Medical Engineering & …, 2020 - Elsevier
Post-myocardial infarction remodeling process is known to alter the mechanical properties of
the heart. Biomechanical parameters, such as tissue stiffness and contractility, would be …

An in silico framework to analyze the anisotropic shear wave mechanics in cardiac shear wave elastography

A Caenen, M Pernot, M Peirlinck… - Physics in Medicine …, 2018 - iopscience.iop.org
Shear wave elastography (SWE) is a potential tool to non-invasively assess cardiac muscle
stiffness. This study focused on the effect of the orthotropic material properties and …

Microstructurally motivated constitutive modeling of heart failure mechanics

AI Hasaballa, VY Wang, GB Sands, AJ Wilson… - Biophysical journal, 2019 - cell.com
Heart failure (HF) is one of the leading causes of death worldwide. HF is associated with
substantial microstructural remodeling, which is linked to changes in left ventricular …

Transmural wave speed gradient may distinguish intrinsic myocardial stiffening from preload-induced changes in operational stiffness in shear wave elastography

A Caenen, S Bézy, A Petrescu, A Werner… - IEEE Transactions …, 2022 - ieeexplore.ieee.org
Background: Shear wave elastography (SWE) is a promising technique to non-invasively
assess myocardial stiffness based on the propagation speed of mechanical waves …

Modelling cardiac tissue growth and remodelling

VY Wang, JR Hussan, H Yousefi, CP Bradley… - Journal of Elasticity, 2017 - Springer
Cardiac growth and remodelling are key phenomena influencing the physiological
performance of the heart and progression of various cardiac diseases. Our basic knowledge …

Transmural remodeling of cardiac microstructure in aged spontaneously hypertensive rats by diffusion tensor MRI

A Giannakidis, GT Gullberg - Frontiers in physiology, 2020 - frontiersin.org
The long-standing high blood pressure (also known as hypertension) overworks the heart.
Microstructural remodeling is a key factor of hypertensive heart disease progression …