Acute respiratory distress syndrome

MA Matthay, RL Zemans, GA Zimmerman… - Nature reviews Disease …, 2019 - nature.com
The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

[HTML][HTML] Integrating molecular pathogenesis and clinical translation in sepsis-induced acute respiratory distress syndrome

JA Englert, C Bobba, RM Baron - JCI insight, 2019 - ncbi.nlm.nih.gov
Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and
mortality and arises after lung infection or infection at extrapulmonary sites. An aberrant host …

Pulmonary angiopathy in severe COVID-19: physiologic, imaging, and hematologic observations

BV Patel, DJ Arachchillage, CA Ridge… - American journal of …, 2020 - atsjournals.org
Rationale: Clinical and epidemiologic data in coronavirus disease (COVID-19) have
accrued rapidly since the outbreak, but few address the underlying pathophysiology …

Effect of P2Y12 inhibitors on survival free of organ support among non–critically ill hospitalized patients with COVID-19: a randomized clinical trial

JS Berger, LZ Kornblith, MN Gong, HR Reynolds… - Jama, 2022 - jamanetwork.com
Importance Platelets represent a potential therapeutic target for improved clinical outcomes
in patients with COVID-19. Objective To evaluate the benefits and risks of adding a P2Y12 …

[HTML][HTML] High levels of eicosanoids and docosanoids in the lungs of intubated COVID‐19 patients

AS Archambault, Y Zaid, V Rakotoarivelo… - The FASEB …, 2021 - ncbi.nlm.nih.gov
Severe acute respiratory syndrome coronavirus 2 is responsible for coronavirus disease
2019 (COVID‐19). While COVID‐19 is often benign, a subset of patients develops severe …

Platelets at the crossroads of pro-inflammatory and resolution pathways during inflammation

N Ludwig, A Hilger, A Zarbock, J Rossaint - Cells, 2022 - mdpi.com
Platelets are among the most abundant cells in the mammalian circulation. Classical platelet
functions in hemostasis and wound healing have been intensively explored and are …

Neutrophil–platelet and monocyte–platelet aggregates in COVID-19 patients

A Le Joncour, L Biard, M Vautier… - Thrombosis and …, 2020 - thieme-connect.com
Coronavirus disease 2019 (COVID-19), a viral respiratory illness caused by the new severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread around the world …

Proresolving Lipid Mediators in the Respiratory System

CN Serhan, BD Levy - Annual Review of Physiology, 2024 - annualreviews.org
Lung inflammation, infection, and injury can lead to critical illness and death. The current
means to pharmacologically treat excessive uncontrolled lung inflammation needs …

Leukocyte function assessed via serial microlitre sampling of peripheral blood from sepsis patients correlates with disease severity

B Jundi, H Ryu, DH Lee, REE Abdulnour… - Nature biomedical …, 2019 - nature.com
Dysregulated leukocyte responses underlie the pathobiology of sepsis, which is a leading
cause of death. However, measures of leukocyte function are not routinely available in …

Design, synthesis, and bioactivity evaluation of novel amide/sulfonamide derivatives as potential anti-inflammatory agents against acute lung injury and ulcerative …

P Chen, J Yang, Y Zhou, X Li, Y Zou, Z Zheng… - European Journal of …, 2023 - Elsevier
The uneven regulation of inflammation is related to various diseases, making anti-
inflammation a potential option for the development of novel therapies. In this study, we …