Wnt signaling is an evolutionary cell‐to‐cell coordination mechanism and it is highly critical
for a variety of physiological processes of an organism's body, including stem cell …

The basic unit of kidney function is the nephron. In the mouse, around 14,000 nephrons form
in a 10-day period extending into early neonatal life, while the human fetus forms the adult …

Fibrosis is the final hallmark of pathological remodeling, which is a major contributor to the
pathogenesis of various chronic diseases and aging-related organ failure to fully control …

Stem cell‐derived kidney organoids contain nephron segments that recapitulate
morphological and functional aspects of the human kidney. However, directed differentiation …

The mammalian kidney is a vital organ with considerable cellular complexity and functional
diversity. Kidney development is notable for requiring distinct but coincident tubulogenic …

Wnt/β-catenin signaling is an evolutionarily conserved, highly complex, key developmental
pathway that regulates cell fate, organ development, tissue homeostasis, as well as injury …

A balance between Six2-dependent self-renewal and canonical Wnt signaling-directed
commitment regulates mammalian nephrogenesis. Intersectional studies using chromatin …

The nephron is the functional unit of the kidney, but the mechanism of nephron formation
during human development is unclear. We conducted a detailed analysis of nephron …

All the information to make a complete, fully functional living organism is encoded within the
genome of the fertilized oocyte. How is this genetic code translated into the vast array of …

Nephron number in the mammalian kidney is known to vary dramatically, with postnatal
renal function directly influenced by nephron complement. What determines final nephron …