Advances in the development of new biomarkers for Alzheimer's disease

TO Klyucherev, P Olszewski, AA Shalimova… - Translational …, 2022 - Springer
Alzheimer's disease (AD) is a complex, heterogeneous, progressive disease and is the most
common type of neurodegenerative dementia. The prevalence of AD is expected to increase …

[HTML][HTML] Alzheimer's disease pathophysiology in the retina

BP Gaire, Y Koronyo, DT Fuchs, H Shi… - Progress in Retinal and …, 2024 - Elsevier
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …

Common pathways in dementia and diabetic retinopathy: understanding the mechanisms of diabetes-related cognitive decline

K Little, M Llorián-Salvador, S Scullion… - Trends in Endocrinology …, 2022 - cell.com
Type 2 diabetes (T2D) is associated with multiple comorbidities, including diabetic
retinopathy (DR) and cognitive decline, and T2D patients have a significantly higher risk of …

Ocular manifestations of Alzheimer's and other neurodegenerative diseases: the prospect of the eye as a tool for the early diagnosis of Alzheimer's disease

P Colligris, MJ Perez de Lara… - Journal of …, 2018 - Wiley Online Library
Dementia, including Alzheimer's disease (AD), is a major disorder, leading to several ocular
manifestations amongst the elderly population. These visual disorders may be due to retinal …

Role of retinal amyloid-β in neurodegenerative diseases: overlapping mechanisms and emerging clinical applications

L Wang, X Mao - International journal of molecular sciences, 2021 - mdpi.com
Amyloid-β (Aβ) accumulations have been identified in the retina for neurodegeneration-
associated disorders like Alzheimer's disease (AD), glaucoma, and age-related macular …

Salvianolic acid B ameliorates retinal deficits in an early-stage alzheimer's disease mouse model through downregulating bace1 and Aβ Generation

M Wang, S Zhang, X Liu, P Wang, Y Zhu… - Acta Pharmacologica …, 2023 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disease with subtle onset, early diagnosis
remains challenging. Accumulating evidence suggests that the emergence of retinal …

Retinal functional and structural changes in the 5xFAD mouse model of Alzheimer's disease

JKH Lim, QX Li, Z He, AJ Vingrys… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease is characterized by the aberrant deposition of protein in the brain and is
the leading cause of dementia worldwide. Increasingly, there have been reports of the …

The retina as a window or mirror of the brain changes detected in Alzheimer's disease: critical aspects to unravel

S Chiquita, AC Rodrigues-Neves, FI Baptista… - Molecular …, 2019 - Springer
Alzheimer's disease is the most frequent cause of dementia worldwide, representing a
global health challenge, with a massive impact on the quality of life of Alzheimer's disease …

OCT Imaging in Murine Models of Alzheimer's Disease in a Systematic Review: Findings, Methodology and Future Perspectives

L Sánchez-Puebla, I López-Cuenca, E Salobrar-García… - Biomedicines, 2024 - mdpi.com
The murine models of Alzheimer's disease (AD) have advanced our understanding of the
pathophysiology. In vivo studies of the retina using optical coherence tomography (OCT) …

Research progress on mechanism of neuroprotective roles of Apelin-13 in prevention and treatment of Alzheimer's disease

T Wan, M Fu, Y Jiang, W Jiang, P Li, S Zhou - Neurochemical research, 2022 - Springer
Alzheimer's disease (AD) is the most common type of dementia. Currently, more than 50
million people live with dementia worldwide, and this number is expected to increase. Some …