Diabetic kidney disease has a high global disease burden and substantially increases the
risk of kidney failure and cardiovascular events. Despite treatment, there is substantial …

A growing appreciation of the pathophysiological interrelatedness of metabolic risk factors
such as obesity and diabetes, chronic kidney disease, and cardiovascular disease has led …

Increasing evidence suggests that renal inflammation contributes to the pathogenesis and
progression of diabetic kidney disease (DKD) and that anti-inflammatory therapies might …

Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

The increasing global prevalence of type 2 diabetes mellitus (T2DM) and chronic kidney
disease (CKD) has prompted research efforts to tackle the growing epidemic of diabetic …

Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …

Chronic kidney disease (CKD) affects many adults worldwide. Persistent low-grade
inflammation is a substantial factor in its development and progression and has correlated …

Significance: Intrarenal oxidative stress plays a critical role in the initiation and progression
of diabetic kidney disease (DKD). Enhanced oxidative stress results from overproduction of …

Abstract NLRP3/IL-1β activation via thioredoxin (TRX)/thioredoxin-interacting protein
(TXNIP) following mitochondria ROS (mtROS) overproduction plays a key role in …

Cardiovascular disease (CVD) is a major cause of death in patients with chronic kidney
disease (CKD). Both conditions are rising in incidence as well as prevalence, creating poor …