As the global population ages, the prevalence of Parkinson's disease (PD) is steadily on the
rise. PD demonstrates chronic and progressive characteristics, and many cases can …

Alzheimer's disease is widely regarded as poorly treated due to poor conceptualization. For
40 years, Alzheimer's disease pathophysiology has focused on two culprits, amyloid-β …

In the last two decades, alpha-synuclein (alpha-syn) assumed a prominent role as a major
component and seeding structure of Lewy bodies (LBs). This concept is driving ongoing …

Abstract Ca 2+/calmodulin-dependent protein kinase II α (CaMKIIα) signaling in the brain
plays a critical role in regulating neuronal Ca 2+ homeostasis. Its dysfunctional activity is …

With emerging genetic association studies, new genes and pathways are revealed as
causative factors in the development of Parkinson's disease (PD). However, many of these …

Mitochondrial damage is associated with the development of Parkinson's disease (PD),
indicating that mitochondrial‐targeted treatments could hold promise as disease‐modifying …

Mitochondrial DNA (mtDNA) deletions which clonally expand in skeletal muscle of patients
with mtDNA maintenance disorders, impair mitochondrial oxidative phosphorylation …

TSP_BIOCELL_49130 707..729 Page 1 Pathogenic genes associated with Parkinson’s disease:
molecular mechanism overview TINGTING LIU1,#; YIWEI HAO2,#; LIFENG ZHAO2,* 1 School …

Parkinson's disease (PD) is a common neurodegenerative disease with a complex
pathogenesis, and a large number of studies have shown that mitochondrial dysfunction is …