Cerebral small vessel disease (cSVD) is a leading cause of ischaemic and haemorrhagic
stroke and a major contributor to dementia. Covert cSVD, which is detectable with brain MRI …

In 2019, the European Society of Cardiology/European Atherosclerosis Society stated that
apolipoprotein B (apoB) was a more accurate marker of cardiovascular risk than low‐density …

The risk factors for nonalcoholic fatty liver disease (NAFLD) have not been clearly identified.
We conducted a Mendelian randomization (MR) study to explore this. Independent genetic …

Large-scale genome-wide association studies conducted over the last decade have
uncovered numerous genetic variants associated with cardiometabolic traits and risk factors …

Stroke is the second leading cause of death worldwide and a complex, heterogeneous
condition. In this review, we provide an overview of the current knowledge on monogenic …

Abstract Apolipoprotein C1 (APOC1) has been found to play an essential part in proliferation
and metastasis of numerous cancers, but related mechanism has not been elucidated …

Objective To investigate the causal role of lipid or apolipoprotein traits in intracerebral
hemorrhage (ICH) and determine the effect of lipid‐lowering interventions on the disease …

Elucidating the causes of stroke is key to developing effective preventive strategies. The
Mendelian randomization approach leverages genetic variants related to an exposure of …

Mendelian randomization can be used as a tool to improve causal inference in
observational studies assessing the role of nutritional factors and metabolites in health and …

While targeting elevated serum levels of low-density lipoprotein cholesterol has been the
mainstay of atherosclerosis prevention and treatment for decades, the evidence regarding …