The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-
phosphate (S1P), in yeast, plants and mammals have shown that it has important functions …

Biologically active sphingolipids have key roles in the regulation of several fundamental
biological processes that are integral to cancer pathogenesis. Recent significant progress in …

Sphingosine‐1‐phosphate (S1P) is a bioactive sphingolipid metabolite involved in many
critical cell processes. It is produced by the phosphorylation of sphingosine by sphingosine …

Abstract Sphingosine-1-phosphate (S1P) is a biologically active metabolite of plasma-
membrane sphingolipids that is essential for immune-cell trafficking. Its concentration is …

▪ Abstract Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …

Osteoclasts are the only somatic cells with bone-resorbing capacity and, as such, they have
a critical role not only in normal bone homeostasis (called 'bone remodelling') but also in the …

Deregulated lipid metabolism may be of particular importance for CNS injuries and
disorders, as this organ has the highest lipid concentration next to adipose tissue …

The bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P), 1 formed by
phosphorylation of sphingosine catalyzed by sphingosine kinase (Fig. 1), is an important …

Mice deficient in sphingosine 1-phosphate receptor type 2 (S1P2) develop diffuse large B
cell lymphoma. However, the role of S1P2 in normal germinal center (GC) physiology is …

Objectives—S1P acts via the S1PR family of G protein–coupled receptors to regulate a
variety of physiological responses. Whereas S1P1R activates Gi-and PI-3-kinase …