Identification and prioritization of environmental organic pollutants: from an analytical and toxicological perspective
Exposure to environmental organic pollutants has triggered significant ecological impacts
and adverse health outcomes, which have been received substantial and increasing …
and adverse health outcomes, which have been received substantial and increasing …
The Tox21 10K compound library: collaborative chemistry advancing toxicology
AM Richard, R Huang, S Waidyanatha… - Chemical Research …, 2020 - ACS Publications
Since 2009, the Tox21 project has screened∼ 8500 chemicals in more than 70 high-
throughput assays, generating upward of 100 million data points, with all data publicly …
throughput assays, generating upward of 100 million data points, with all data publicly …
admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties
Absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties play key
roles in the discovery/development of drugs, pesticides, food additives, consumer products …
roles in the discovery/development of drugs, pesticides, food additives, consumer products …
Improving the human hazard characterization of chemicals: a Tox21 update
RR Tice, CP Austin, RJ Kavlock… - Environmental health …, 2013 - ehp.niehs.nih.gov
Background: In 2008, the National Institute of Environmental Health Sciences/National
Toxicology Program, the US Environmental Protection Agency's National Center for …
Toxicology Program, the US Environmental Protection Agency's National Center for …
Benchmarking organic micropollutants in wastewater, recycled water and drinking water with in vitro bioassays
Thousands of organic micropollutants and their transformation products occur in water.
Although often present at low concentrations, individual compounds contribute to mixture …
Although often present at low concentrations, individual compounds contribute to mixture …
Effect-based trigger values for in vitro and in vivo bioassays performed on surface water extracts supporting the environmental quality standards (EQS) of the …
Abstract Effect-based methods including cell-based bioassays, reporter gene assays and
whole-organism assays have been applied for decades in water quality monitoring and …
whole-organism assays have been applied for decades in water quality monitoring and …
Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space
Chemical toxicity can arise from disruption of specific biomolecular functions or through
more generalized cell stress and cytotoxicity-mediated processes. Here, responses of 1060 …
more generalized cell stress and cytotoxicity-mediated processes. Here, responses of 1060 …
Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management
R Kavlock, K Chandler, K Houck, S Hunter… - Chemical research in …, 2012 - ACS Publications
The field of toxicology is on the cusp of a major transformation in how the safety and hazard
of chemicals are evaluated for potential effects on human health and the environment …
of chemicals are evaluated for potential effects on human health and the environment …
Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing
BA Wetmore, JF Wambaugh, B Allen… - Toxicological …, 2015 - academic.oup.com
We previously integrated dosimetry and exposure with high-throughput screening (HTS) to
enhance the utility of ToxCast HTS data by translating in vitro bioactivity concentrations to …
enhance the utility of ToxCast HTS data by translating in vitro bioactivity concentrations to …
Impact of untreated wastewater on a major European river evaluated with a combination of in vitro bioassays and chemical analysis
Complex mixtures of micropollutants, including pesticides, pharmaceuticals and industrial
chemicals emitted by wastewater effluents to European rivers may compromise the quality of …
chemicals emitted by wastewater effluents to European rivers may compromise the quality of …