Central gain control in tinnitus and hyperacusis

BD Auerbach, PV Rodrigues, RJ Salvi - Frontiers in neurology, 2014 - frontiersin.org
Sensorineural hearing loss induced by noise or ototoxic drug exposure reduces the neural
activity transmitted from the cochlea to the central auditory system. Despite a reduced …

The neuroscience of tinnitus

JJ Eggermont, LE Roberts - Trends in neurosciences, 2004 - cell.com
Tinnitus is an auditory phantom sensation (ringing of the ears) experienced when no
external sound is present. Most but not all cases are associated with hearing loss induced …

[HTML][HTML] Advances in the neurobiology of hearing disorders: recent developments regarding the basis of tinnitus and hyperacusis

M Knipper, P Van Dijk, I Nunes, L Rüttiger… - Progress in …, 2013 - Elsevier
The prevalence of hearing problems in the Western world has, due to aging of the
population, doubled over the past 30 years. Thereby, noise-induced hearing loss is an …

An integrative model of tinnitus based on a central gain controlling neural sensitivity

AJ Noreña - Neuroscience & Biobehavioral Reviews, 2011 - Elsevier
The purpose of the current review is to propose a model highlighting the putative
connections between hearing loss and the phantom perception of tinnitus (tinnitus being …

Tinnitus-related neural activity: theories of generation, propagation, and centralization

AJ Noreña, BJ Farley - Hearing research, 2013 - Elsevier
The neuroscience of tinnitus represents an ideal model to explore central issues in brain
functioning such as the formation of auditory percepts, in addition to opening up new …

Why do hearing aids fail to restore normal auditory perception?

NA Lesica - Trends in neurosciences, 2018 - cell.com
Hearing loss is a widespread condition that is linked to declines in quality of life and mental
health. Hearing aids remain the treatment of choice, but, unfortunately, even state-of-the-art …

The auditory sensitivity is increased in tinnitus ears

S Hébert, P Fournier, A Noreña - Journal of Neuroscience, 2013 - Soc Neuroscience
Increased auditory sensitivity, also called hyperacusis, is a pervasive complaint of people
with tinnitus. The high prevalence of hyperacusis in tinnitus subjects suggests that both …

Noise overexposure alters long-term somatosensory-auditory processing in the dorsal cochlear nucleus—possible basis for tinnitus-related hyperactivity?

S Dehmel, S Pradhan, S Koehler… - Journal of …, 2012 - Soc Neuroscience
The dorsal cochlear nucleus (DCN) is the first neural site of bimodal auditory-somatosensory
integration. Previous studies have shown that stimulation of somatosensory pathways …

An active loudness model suggesting tinnitus as increased central noise and hyperacusis as increased nonlinear gain

FG Zeng - Hearing research, 2013 - Elsevier
The present study uses a systems engineering approach to delineate the relationship
between tinnitus and hyperacusis as a result of either hearing loss in the ear or an …

The reduced cochlear output and the failure to adapt the central auditory response causes tinnitus in noise exposed rats

L Rüttiger, W Singer, R Panford-Walsh, M Matsumoto… - PloS one, 2013 - journals.plos.org
Tinnitus is proposed to be caused by decreased central input from the cochlea, followed by
increased spontaneous and evoked subcortical activity that is interpreted as compensation …