[HTML][HTML] Metabolism, toxicity and anticancer activities of arsenic compounds

I Khairul, QQ Wang, YH Jiang, C Wang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
A variety of studies indicated that inorganic arsenic and its methylated metabolites have
paradoxical effects, namely, carcinogenic and anticancer effects. Epidemiological studies …

Aquatic arsenic: toxicity, speciation, transformations, and remediation

VK Sharma, M Sohn - Environment international, 2009 - Elsevier
This paper reviews the current knowledge on the toxicity, speciation and biogeochemistry of
arsenic in aquatic environmental systems. The toxicity of arsenic is highly dependent on the …

Metabolism of arsenic and its toxicological relevance

T Watanabe, S Hirano - Archives of toxicology, 2013 - Springer
Arsenic is a worldwide environmental pollutant and a human carcinogen. It is well
recognized that the toxicity of arsenicals largely depends on the oxidoreduction states …

A new metabolic pathway of arsenite: arsenic–glutathione complexes are substrates for human arsenic methyltransferase Cyt19

T Hayakawa, Y Kobayashi, X Cui, S Hirano - Archives of toxicology, 2005 - Springer
The metabolism of arsenic is generally accepted to proceed by repetitive reduction and
oxidative methylation; the latter is mediated by arsenic methyltransferase (Cyt19). In human …

Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment

SM Cohen, LL Arnold, M Eldan, AS Lewis… - Critical reviews in …, 2006 - Taylor & Francis
Monomethylarsonic acid (MMA V) and dimethylarsinic acid (DMA V) are active ingredients in
pesticidal products used mainly for weed control. MMA V and DMA V are also metabolites of …

Comparative cytotoxicity of fourteen trivalent and pentavalent arsenic species determined using real-time cell sensing

B Moe, H Peng, X Lu, B Chen, LWL Chen… - Journal of …, 2016 - Elsevier
The occurrence of a large number of diverse arsenic species in the environment and in
biological systems makes it important to compare their relative toxicity. The toxicity of arsenic …

Arsenic exposure, urinary arsenic speciation, and peripheral vascular disease in blackfoot disease-hyperendemic villages in Taiwan

CH Tseng, YK Huang, YL Huang, CJ Chung… - Toxicology and applied …, 2005 - Elsevier
Long-term exposure to ingested inorganic arsenic is associated with peripheral vascular
disease (PVD) in the blackfoot disease (BFD)-hyperendemic area in Taiwan. This study …

Proteome analysis of maize roots reveals that oxidative stress is a main contributing factor to plant arsenic toxicity

R Requejo, M Tena - Phytochemistry, 2005 - Elsevier
To gain insight into plant responses to arsenic, the effect of arsenic exposure on maize (Zea
mays L.) root proteome has been examined. Maize seedlings were fed hydroponically with …

Multi-walled carbon nanotubes injure the plasma membrane of macrophages

S Hirano, S Kanno, A Furuyama - Toxicology and applied pharmacology, 2008 - Elsevier
Carbon nanotubes (CNTs) are emerging nanotechnology materials which are likely to be
mass-produced in the near future. However, prior to mass-production, certain health-related …

Dose-response for assessing the cancer risk of inorganic arsenic in drinking water: the scientific basis for use of a threshold approach

JS Tsuji, ET Chang, PR Gentry, HJ Clewell… - Critical reviews in …, 2019 - Taylor & Francis
The biologic effects of inorganic arsenic predominantly involve reaction of the trivalent forms
with sulfhydryl groups in critical proteins in target cells, potentially leading to various …