Pathophysiology and current clinical management of preeclampsia

LM Amaral, K Wallace, M Owens, B LaMarca - Current hypertension …, 2017 - Springer
Preeclampsia is characterized by blood pressure greater than 140/90 mmHg in the second
half of pregnancy. This disease is a major contributor to preterm and low birth weight babies …

Pathogenesis of preeclampsia and therapeutic approaches targeting the placenta

MK Jena, NR Sharma, M Petitt, D Maulik, NR Nayak - Biomolecules, 2020 - mdpi.com
Preeclampsia (PE) is a serious pregnancy complication, affecting about 5–7% of
pregnancies worldwide and is characterized by hypertension and damage to multiple …

Preeclampsia: long-term consequences for vascular health

LM Amaral, MW Cunningham Jr… - Vascular health and …, 2015 - Taylor & Francis
Preeclampsia (PE) is a pregnancy-specific syndrome and one of the leading causes of
preterm birth, neonatal and maternal morbidity and mortality. This disease is characterized …

[HTML][HTML] Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension

MF Montenegro, JH Amaral, LC Pinheiro… - Free Radical Biology …, 2011 - Elsevier
Dietary nitrite and nitrate are important sources of nitric oxide (NO). However, the use of
nitrite as an antihypertensive drug may be limited by increased oxidative stress associated …

The role of arginine, homoarginine and nitric oxide in pregnancy

A Khalil, L Hardman, PO´ Brien - Amino acids, 2015 - Springer
Normal pregnancy leads to profound maternal hemodynamic changes, including increased
blood volume and vasodilatation. Several vasodilator mediators are implicated, including …

17-hydroxyprogesterone caproate significantly improves clinical characteristics of preeclampsia in the reduced uterine perfusion pressure rat model

LM Amaral, DC Cornelius, A Harmon, J Moseley… - …, 2015 - Am Heart Assoc
Preeclampsia is characterized by increased uterine artery resistance index, chronic immune
activation, and decreased circulating nitric oxide levels. 17-α-Hydroxyprogesterone caproate …

[HTML][HTML] Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension

JH Amaral, GC Ferreira, LC Pinheiro, MF Montenegro… - Redox biology, 2015 - Elsevier
Hypertension is a common disease that includes oxidative stress as a major feature, and
oxidative stress impairs physiological nitric oxide (NO) activity promoting cardiovascular …

Genetic variants in preeclampsia: Lessons from studies in Latin-American populations

RT Michita, VL Kaminski, JAB Chies - Frontiers in Physiology, 2018 - frontiersin.org
Placental vascularization is a tightly regulated physiological process in which the maternal
immune system plays a fundamental role. Vascularization of the maternal-placental interface …

Analysis of SIRT1 Expression in Plasma and in an In Vitro Model of Preeclampsia

S Viana-Mattioli, P Nunes, R Cavalli… - … Medicine and Cellular …, 2020 - Wiley Online Library
Preeclampsia (PE) is a pregnancy‐specific disorder that affects 3–8% expecting mothers
worldwide being one of the main causes of maternal and fetal morbidity and mortality. The …

Plasma eNOS concentration in healthy pregnancy and in hypertensive disorders of pregnancy: Evidence of reduced concentrations in pre-eclampsia from two …

JNS Kaihara, CK Minami, MTS Peraçoli… - Diseases, 2023 - mdpi.com
Hypertensive disorders of pregnancy (HDP), comprising gestational hypertension (GH) and
pre-eclampsia (PE), are leading causes of maternal and perinatal morbidity and mortality …