The majority of monoclonal antibody (mAb) therapeutics possess the ability to engage
innate immune effectors through interactions mediated by their fragment crystallizable (Fc) …

Immune checkpoint inhibitors (ICI) revolutionized the field of immuno-oncology and opened
new avenues towards the development of novel assets to achieve durable immune control …

In addition to its role as a TB vaccine, BCG has been shown to elicit heterologous protection
against many other pathogens including viruses through a process termed trained immunity …

Macrophages are important effector cells of the innate immune system and are also major
components of the tumor microenvironment (TME). Macrophages that are abundant in the …

The number and phenotype of macrophages are closely related to tumor growth and
prognosis. Macrophages are recruited to (and polarized at) the tumor site thereby promoting …

Monoclonal antibodies (mAbs) are one of the most widely used drug platforms for infectious
diseases or cancer therapeutics because they selectively target pathogens, infectious cells …

Therapeutic monoclonal antibodies (mAbs) have become one of the fastest growing classes
of drugs in recent years and are approved for the treatment of a wide range of indications …

The costimulatory receptor 4-1BB is expressed on activated immune cells, including
activated T cells. Antibodies targeting 4-1BB enhance the proliferation and survival of …

In the last decade, it has been well-established that tumor-infiltrating myeloid cells fuel not
only the process of carcinogenesis through cancer-related inflammation mechanisms, but …

The innate immune system provides the first line of defense against pathogen infection
though also influences pathways involved in cancer immunosurveillance. The innate …