Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

H Sies, VV Belousov, NS Chandel, MJ Davies… - … reviews Molecular cell …, 2022 - nature.com
Abstract 'Reactive oxygen species'(ROS) is a generic term that defines a wide variety of
oxidant molecules with vastly different properties and biological functions that range from …

Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

MP Murphy, H Bayir, V Belousov, CJ Chang… - Nature …, 2022 - nature.com
Multiple roles of reactive oxygen species (ROS) and their consequences for health and
disease are emerging throughout biological sciences. This development has led …

Mitochondria-targeted triphenylphosphonium-based compounds: syntheses, mechanisms of action, and therapeutic and diagnostic applications

J Zielonka, J Joseph, A Sikora, M Hardy… - Chemical …, 2017 - ACS Publications
Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Biomarkers of oxidative stress in metabolic syndrome and associated diseases

R Vona, L Gambardella, C Cittadini… - Oxidative medicine …, 2019 - Wiley Online Library
Metabolic syndrome (MS) represents worldwide public health issue characterized by a set of
cardiovascular risk factors including obesity, diabetes, dyslipidemia, hypertension, and …

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

RJ Weaver, EA Blomme, AE Chadwick… - Nature Reviews Drug …, 2020 - nature.com
Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial
pathophysiological process that cannot yet be recapitulated in a single in vitro model …

Methods for detection of mitochondrial and cellular reactive oxygen species

SI Dikalov, DG Harrison - Antioxidants & redox signaling, 2014 - liebertpub.com
Significance: Mitochondrial and cellular reactive oxygen species (ROS) play important roles
in both physiological and pathological processes. Different ROS, such as superoxide (O2•−) …

[HTML][HTML] Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and …

B Kalyanaraman, G Cheng, M Hardy, O Ouari… - Redox biology, 2018 - Elsevier
Reactive oxygen species (ROS) have been implicated in tumorigenesis (tumor initiation,
tumor progression, and metastasis). Of the many cellular sources of ROS generation, the …

The challenges of using fluorescent probes to detect and quantify specific reactive oxygen species in living cells

CC Winterbourn - Biochimica et Biophysica Acta (BBA)-General Subjects, 2014 - Elsevier
Background Small molecule fluorescent probes are vital tools for monitoring reactive oxygen
species in cells. Scope of review The types of probe available, the extent to which they are …

Advances in measuring cancer cell metabolism with subcellular resolution

V Ruiz-Rodado, A Lita, M Larion - Nature Methods, 2022 - nature.com
Characterizing metabolism in cancer is crucial for understanding tumor biology and for
developing potential therapies. Although most metabolic investigations analyze averaged …

A highly specific fluorescent probe for hypochlorous acid and its application in imaging microbe-induced HOCl production

Q Xu, KA Lee, S Lee, KM Lee, WJ Lee… - Journal of the American …, 2013 - ACS Publications
Oxidative stress induced by reactive oxygen species (ROS) plays crucial roles in a wide
range of physiological processes and is also implicated in various diseases, including …