Metazoan tissue specification is associated with integration of macrophage lineage cells in
sub-tissular niches to promote tissue development and homeostasis. Oncogenic …

Iron is indispensable for normal body functions across species because of its critical roles in
red blood cell function and many essential proteins and enzymes required for numerous …

Ferroptosis is a necrotic form of regulated cell death (RCD) mediated by phospholipid
peroxidation in association with free iron-mediated Fenton reactions. Disrupted iron …

Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and
genetic determinants. We have previously identified iron-responsive element–binding …

As the first line of defence in the lung, alveolar macrophage contributes to maintaining lung
immune homoeostasis. Characterized by the heterogeneity and plasticity, macrophages …

Airway macrophages (AMs) play key roles in the maintenance of lung immune tolerance.
Tissue tailored, highly specialised and strategically positioned, AMs are critical sentinels of …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a devastating progressive disease with
limited therapeutic options. Airway macrophages (AMs) are key components of the defense …

A strong mechanistic link between the regulation of iron homeostasis and oxygen sensing is
evident in the lung, where both systems must be properly controlled to maintain lung …

Chronic obstructive pulmonary disease (COPD) is a debilitating inflammatory lung disease
and the third leading cause of death worldwide (1). COPD is characterized by three major …

Iron is essential for many biological processes, however, too much or too little iron can result
in a wide variety of pathological consequences, depending on the organ system, tissue or …