Originally confined to the initiation of parturition and milk ejection after birth, the
hypothalamic nonapeptide oxytocin (OT) is now recognized as a critical determinant of …

Pain is a ubiquitously unpleasant feeling among humans as well as many animal species
often caused by actual and potential tissue damage. However, it is absolutely crucial for our …

Oxytocin (OT) has emerged as a mediator of endogenous analgesia in behavioral and
electrophysiological experiments. In fact, OT receptors (OTRs) in the spinal dorsal horn …

Background There is a need for novel analgesics with favorable risk to benefit profiles.
Oxytocin has recently gained attention for its potential analgesic properties. Aim The aim of …

Despite the high incidence of neuropathic pain, its mechanism remains unclear. Oxytocin
(OXT) is an established endogenous polypeptide produced in the supraoptic nucleus (SON) …

The hypothalamic non-apeptide oxytocin (OT) has several physiological functions, ranging
from lactation to social attachment (Gimpl and Fahrenholz, 2001). More recently, a collection …

Oxytocin is a hypothalamic neuropeptide involved in the inhibition of nociception
transmission at spinal dorsal horn (SDH) level (the first station where the incoming …

BACKGROUND: We demonstrated previously that angiotensin IV (Ang IV) and LVV-
hemorphin 7 (LVV-H7) act through the blockade of insulin-regulated aminopeptidase to …

The search for new ligands to treat neuropathic pain remains a challenge. Recently,
oxytocin has emerged as an interesting molecule modulating nociception at central and …

The medullary dorsal horn (MDH or Sp5c/C1 region) plays a key role modulating the
nociceptive input arriving from craniofacial structures. Some reports suggest that oxytocin …