Extracorporeal circulation (ECC) systems, including cardiopulmonary bypass, and
extracorporeal membrane oxygenation have been an irreplaceable part of the …

Despite the advancements in medical treatment, mechanical support, and stem cell therapy,
heart transplantation remains the most effective treatment for selected patients with …

An ex vivo heart perfusion device preserves the donor heart in a warm beating state during
transfer between extraction and implantation surgeries. One of the current challenges …

Ex situ heart perfusion (ESHP) has emerged as an important strategy to preserve donation
after brain death (DBD) and donation after circulatory death (DCD) donor hearts. Clinically …

Ex vivo (outside of the body) working heart models enable the evaluation of isolated hearts.
They are envisioned to play an important role in increasing the currently low utilization rate …

Background Existing working heart models for ex vivo functional evaluation of donor hearts
often use cardiac afterloads made up of discrete resistive and compliant elements. This …

Due to the discrepancy between patients awaiting a heart transplant and the availability of
donor hearts, strategies to expand the donor pool and improve the transplant's success are …

BACKGROUND Evidence suggests that hearts that are perfused under ex-situ conditions
lose normal coronary vasomotor tone and experience contractile failure over a few hours …

The availability of thoracic organ transplantation as the treatment of choice for end-stage
cardiac or pulmonary diseases is limited by the insufficient number of donor organs from …

Abstract Purpose of Review The purpose of this manuscript is to briefly review the past,
present, and potential future of machine perfusion (MP) of the donor heart and to highlight its …