Cholesterol is essential for membrane biogenesis, cell proliferation, and differentiation. The
role of cholesterol in cancer development and the regulation of cholesterol synthesis are still …

Background chemotherapy drugs are the common therapy for cancer cells with side effects.
Recent studies reported that natural products may contribute to decreasing the side effects …

Background Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers
worldwide. Overexpression of EMT master transcription factors can promote differentiated …

The Warburg effect is a prominent metabolic feature associated with neoplastic diseases;
however, the underlying mechanism remains incompletely understood. TAp73, a structural …

Introduction. Esophagus squamous cell carcinoma (ESCC) has a poor prognosis, a high
rate of metastasis, and rapid clinical progression. One hypothesis is that therapeutic failure …

Human tumor cell lines are extremely important tools for cancer research, but a significant
percentage is cross-contaminated with other cells. Short tandem repeat (STR) profiling is the …

The sporoderm‑broken spores of Ganoderma lucidum (G. lucidum) polysaccharide (BSGLP)
have been demonstrated to inhibit carcinogenesis in several types of cancer. However, to …

Cell lines are widely used as in vitro models of tumorigenesis. However, an increasing
number of researchers have found that cell lines differ from their sourced tumour samples …

Terminal exhaustion is a critical barrier to antitumor immunity. By integrating and analyzing
single-cell RNA-sequencing and single-cell assay for transposase-accessible chromatin …

Establishment of continuous cell lines from human normal and tumor tissues is an extended
and useful methodology for molecular characterization of cancer pathophysiology and drug …