Despite improvements in the mortality rates of preterm infants, rates of germinal matrix
intraventricular hemorrhage (IVH) have remained static with an overall incidence of 25% in …

Cerebrovascular reactivity defines the ability of the cerebral vasculature to regulate its
resistance in response to both local and systemic factors to ensure an adequate cerebral …

Inflammation is an important mediator of secondary neurological injury after traumatic brain
injury (TBI). Endocannabinoids, endogenously produced arachidonate based lipids, have …

Importance Preterm infants with varying degrees of anemia have different tissue oxygen
saturation responses to red blood cell (RBC) transfusion, and low cerebral saturation may …

Abstract Near-infrared spectroscopy (NIRS)-based monitoring of regional tissue oxygenation
(rSO2) is becoming more commonplace in the neonatal intensive care unit (NICU). While …

Two recent pilot randomized controlled trials highlight the potential of cerebral oxygenation
monitoring to direct management in the delivery room and the neonatal intensive care unit …

Aim Cerebral hypoxia has been associated with neurodevelopmental impairment. We
studied whether reducing cerebral hypoxia in extremely preterm infants during the first 72 …

With advances in neonatal care, survival of premature infants at the limits of viability has
improved significantly. Despite these improvement in mortality, infants born at 22–24 weeks …

Infants requiring admission to the neonatal intensive care unit (NICU) are particularly
vulnerable to developing brain injury. The severity of the underlying clinical conditions and …

Near-infrared spectroscopy (NIRS) allows for continuous, non-invasive monitoring of end-
organ tissue oxygenation. The use of NIRS, cerebral NIRS (cNIRS) in particular, in neonatal …