Lupeol and its derivatives as anticancer and anti-inflammatory agents: Molecular mechanisms and therapeutic efficacy

K Liu, X Zhang, L Xie, M Deng, H Chen, J Song… - Pharmacological …, 2021 - Elsevier
Lupeol is a natural triterpenoid that widely exists in edible fruits and vegetables, and
medicinal plants. In the last decade, a plethora of studies on the pharmacological activities …

Comparison of anticancer drug toxicities: paradigm shift in adverse effect profile

D Basak, S Arrighi, Y Darwiche, S Deb - Life, 2021 - mdpi.com
The inception of cancer treatment with chemotherapeutics began in the 1940s with nitrogen
mustards that were initially employed as weapons in World War II. Since then, treatment …

Chemotherapy impairs ovarian function through excessive ROS-induced ferroptosis

S Zhang, Q Liu, M Chang, Y Pan, BH Yahaya… - Cell death & …, 2023 - nature.com
Chemotherapy was conventionally applied to kill cancer cells, but regrettably, they also
induce damage to normal cells with high-proliferative capacity resulting in cardiotoxicity …

Neuroinflammation: a potential risk for dementia

MA Ahmad, O Kareem, M Khushtar, M Akbar… - International journal of …, 2022 - mdpi.com
Dementia is a neurodegenerative condition that is considered a major factor contributing to
cognitive decline that reduces independent function. Pathophysiological pathways are not …

[图书][B] An introduction to theories of learning

MH Olson, JJ Ramírez - 2020 - taylorfrancis.com
Since its first edition, An Introduction to Theories of Learning has provided a uniquely
sweeping review of the major learning theories from the 20th century that profoundly …

Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer

C Rocca, T Soda, EM De Francesco, M Fiorillo… - Journal of Translational …, 2023 - Springer
A large body of evidence indicates the existence of a complex pathophysiological
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …

Lipid metabolism in autoimmune rheumatic disease: implications for modern and conventional therapies

G Robinson, I Pineda-Torra, C Ciurtin… - The Journal of …, 2022 - Am Soc Clin Investig
Suppressing inflammation has been the primary focus of therapies in autoimmune rheumatic
diseases (AIRDs), including rheumatoid arthritis and systemic lupus erythematosus …

Dual role of endoplasmic reticulum stress-mediated unfolded protein response signaling pathway in carcinogenesis

N Siwecka, W Rozpędek, D Pytel… - International journal of …, 2019 - mdpi.com
Cancer constitutes a grave problem nowadays in view of the fact that it has become one of
the main causes of death worldwide. Poor clinical prognosis is presumably due to cancer …

The nitrogen mustards

MS Highley, B Landuyt, H Prenen, PG Harper… - Pharmacological …, 2022 - Elsevier
The nitrogen mustards are powerful cytotoxic and lymphoablative agents and have been
used for more than 60 years. They are employed in the treatment of cancers, sarcomas, and …

Neuroprotective effect of quercetin and nano-quercetin against cyclophosphamide-induced oxidative stress in the rat brain: role of Nrf2/HO-1/Keap-1 signaling …

DA AbdElrazek, MA Ibrahim, NH Hassan, EI Hassanen… - Neurotoxicology, 2023 - Elsevier
Quercetin (Qu) is a powerful flavanol antioxidant that is naturally found in plants and is part
of the flavonoid family. Qu has a wide range of biological properties, such as …