Within the superfamily of pentameric ligand-gated ion channels, cholinergic nicotinic
receptors (nAChRs) were classically identified to mediate synaptic transmission in the …

Nicotinic acetylcholine receptors (nAChRs) are master regulators of immune functions via
the cholinergic anti-inflammatory pathway and are expressed in microglia, the brain's …

Activation of nicotinic acetylcholine receptors (nAChRs) expressed by innate immune cells
can attenuate pro-inflammatory responses. Silent nAChR agonists, which down-modulate …

In the nervous system, nicotinic acetylcholine receptors (nAChRs) rapidly transduce a
chemical signal into one that is electrical via ligand-gated ion flux through the central …

Introduction Hearing loss is a major health problem, impacting education, communication,
interpersonal relationships, and mental health. Drugs that prevent or restore hearing are …

Nicotinic acetylcholine receptors (nAChRs) are a subfamily of pentameric ligand-gated ion
channels with members identified in most eumetazoan clades. In vertebrates, they are …

Unlike most neuronal nicotinic acetylcholine receptor (nAChR) subunits, α7, α9, and α10
subunits are able to form functional homo-or heteromeric receptors without any β subunits …

After the transition to life on land, tympanic middle ears emerged separately in different
groups of tetrapods, facilitating the efficient detection of airborne sounds and paving the way …

How do organisms without specialized auditory systems perceive and transduce sound? In
this issue of Neuron, Iliff et al.(2021) investigate the functional mechanism of airborne sound …