Inflammation and tumor progression: signaling pathways and targeted intervention

H Zhao, L Wu, G Yan, Y Chen, M Zhou… - Signal transduction and …, 2021 - nature.com
Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

Engineering strategies to enhance oncolytic viruses in cancer immunotherapy

Y Tian, D Xie, L Yang - Signal transduction and targeted therapy, 2022 - nature.com
Oncolytic viruses (OVs) are emerging as potentially useful platforms in treatment methods for
patients with tumors. They preferentially target and kill tumor cells, leaving healthy cells …

The emerging field of oncolytic virus-based cancer immunotherapy

R Ma, Z Li, EA Chiocca, MA Caligiuri, J Yu - Trends in cancer, 2023 - cell.com
Oncolytic viruses (OVs) provide novel and promising therapeutic options for patients with
cancers resistant to traditional therapies. Natural or genetically modified OVs are …

Optimizing oncolytic virotherapy in cancer treatment

K Harrington, DJ Freeman, B Kelly, J Harper… - Nature reviews Drug …, 2019 - nature.com
In the wake of the success of modern immunotherapy, oncolytic viruses (OVs) are currently
seen as a potential therapeutic option for patients with cancer who do not respond or fail to …

Oncolytic Parapoxvirus induces Gasdermin E-mediated pyroptosis and activates antitumor immunity

J Lin, S Sun, K Zhao, F Gao, R Wang, Q Li… - Nature …, 2023 - nature.com
The advantage of oncolytic viruses (OV) in cancer therapy is their dual effect of directly
killing tumours while prompting anti-tumour immune response. Oncolytic parapoxvirus ovis …

Oncolytic virus therapy: A new era of cancer treatment at dawn

H Fukuhara, Y Ino, T Todo - Cancer science, 2016 - Wiley Online Library
Oncolytic virus therapy is perhaps the next major breakthrough in cancer treatment following
the success in immunotherapy using immune checkpoint inhibitors. Oncolytic viruses are …

Oncolytic viruses as engineering platforms for combination immunotherapy

K Twumasi-Boateng, JL Pettigrew, YYE Kwok… - Nature Reviews …, 2018 - nature.com
To effectively build on the recent successes of immune checkpoint blockade, adoptive T cell
therapy and cancer vaccines, it is critical to rationally design combination strategies that will …

Oncolytic virus immunotherapy: future prospects for oncology

J Raja, JM Ludwig, SN Gettinger, KA Schalper… - … for immunotherapy of …, 2018 - Springer
Background Immunotherapy is at the forefront of modern oncologic care. Various novel
therapies have targeted all three layers of tumor biology: tumor, niche, and immune system …

Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications

A Wicki, D Witzigmann, V Balasubramanian… - Journal of controlled …, 2015 - Elsevier
Cancer is a leading cause of death worldwide. Currently available therapies are inadequate
and spur demand for improved technologies. Rapid growth in nanotechnology towards the …

Oncolytic virotherapy as immunotherapy

A Melcher, K Harrington, R Vile - Science, 2021 - science.org
Oncolytic virus (OV) therapy is now something of a misnomer. The initial paradigm was that
naturally occurring or genetically engineered viruses would preferentially infect, replicate in …