Lipoprotein (a): a genetically determined, causal, and prevalent risk factor for atherosclerotic cardiovascular disease: a scientific statement from the American Heart …

G Reyes-Soffer, HN Ginsberg, L Berglund… - … , and vascular biology, 2022 - Am Heart Assoc
High levels of lipoprotein (a)[Lp (a)], an apoB100-containing lipoprotein, are an independent
and causal risk factor for atherosclerotic cardiovascular diseases through mechanisms …

Lipoprotein (a) and its significance in cardiovascular disease: a review

FD Lau, RP Giugliano - JAMA cardiology, 2022 - jamanetwork.com
Importance Lipoprotein (a)(Lp [a]) is a low-density lipoprotein (LDL) cholesterol–like particle
bound to apolipoprotein (a). This novel marker of cardiovascular disease acts through …

[HTML][HTML] Small interfering RNA to reduce lipoprotein (a) in cardiovascular disease

ML O'Donoghue, RS Rosenson… - … England Journal of …, 2022 - Mass Medical Soc
Background Lipoprotein (a) is a presumed risk factor for atherosclerotic cardiovascular
disease. Olpasiran is a small interfering RNA that reduces lipoprotein (a) synthesis in the …

Residual cardiovascular risk at low LDL: remnants, lipoprotein (a), and inflammation

RC Hoogeveen, CM Ballantyne - Clinical chemistry, 2021 - academic.oup.com
Background Current guidelines target low-density lipoprotein cholesterol (LDL-C)
concentrations to reduce atherosclerotic cardiovascular disease (ASCVD) risk, and yet …

[HTML][HTML] Ten things to know about ten cardiovascular disease risk factors

HE Bays, PR Taub, E Epstein, ED Michos… - American journal of …, 2021 - Elsevier
Given rapid advancements in medical science, it is often challenging for the busy clinician to
remain up-to-date on the fundamental and multifaceted aspects of preventive cardiology and …

[HTML][HTML] Study design and rationale for the Olpasiran trials of Cardiovascular Events And lipoproteiN (a) reduction-DOSE finding study (OCEAN (a)-DOSE)

ML O'Donoghue, JAG López, B Knusel, B Gencer… - American Heart …, 2022 - Elsevier
Background Data support lipoprotein (a)(Lp [Lp (a)]) being a risk factor for atherosclerotic
cardiovascular disease (ASCVD). Olpasiran is a small interfering RNA molecule that …

Ancestry, Lipoprotein(a), and Cardiovascular Risk Thresholds: JACC Review Topic of the Week

S Tsimikas, SM Marcovina - Journal of the American College of Cardiology, 2022 - jacc.org
This study reviews ancestral differences in the genetics of the LPA gene, risk categories of
elevated lipoprotein (a)[Lp (a)] as defined by guidelines, ancestry-specific Lp (a) risk …

Lipoprotein (a) in atherosclerotic diseases: from pathophysiology to diagnosis and treatment

S Lampsas, M Xenou, E Oikonomou, P Pantelidis… - Molecules, 2023 - mdpi.com
Lipoprotein (a)(Lp (a)) is a low-density lipoprotein (LDL) cholesterol-like particle bound to
apolipoprotein (a). Increased Lp (a) levels are an independent, heritable causal risk factor …

2023 Chinese guideline for lipid management

JJ Li, SP Zhao, D Zhao, GP Lu, DQ Peng… - Frontiers in …, 2023 - frontiersin.org
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death among urban
and rural residents in China, and elevated low-density lipoprotein cholesterol (LDL-C) is a …

Familial hypercholesterolaemia: evolving knowledge for designing adaptive models of care

GF Watts, SS Gidding, P Mata, J Pang… - Nature Reviews …, 2020 - nature.com
Optimal care for familial hypercholesterolaemia (FH) requires patient-centred management,
multidisciplinary teamwork, involvement of primary care practitioners, patient networks …