Current methods for hyperpolarized [1‐13C]pyruvate MRI human studies

PEZ Larson, JML Bernard, JA Bankson… - Magnetic resonance …, 2024 - Wiley Online Library
Abstract MRI with hyperpolarized (HP) 13C agents, also known as HP 13C MRI, can
measure processes such as localized metabolism that is altered in numerous cancers, liver …

[HTML][HTML] Hyperpolarized [2–13C] pyruvate MR molecular imaging with whole brain coverage

BT Chung, Y Kim, JW Gordon, HY Chen, AW Autry… - NeuroImage, 2023 - Elsevier
Abstract Hyperpolarized (HP) 13 C Magnetic Resonance Imaging (MRI) was applied for the
first time to image and quantify the uptake and metabolism of [2–13 C] pyruvate in the …

Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges

V Batarchuk, Y Shepelytskyi, V Grynko… - International Journal of …, 2024 - mdpi.com
Molecular magnetic resonance imaging (MRI) is an emerging field that is set to revolutionize
our perspective of disease diagnosis, treatment efficacy monitoring, and precision medicine …

[HTML][HTML] 129Xe MRI ventilation defects in asthma: what is the upper limit of normal and minimal clinically important difference?

MJ McIntosh, A Biancaniello, HK Kooner, A Bhalla… - Academic …, 2023 - Elsevier
Rationale and Objectives The minimal clinically important difference (MCID) and upper limit
of normal (ULN) for MRI ventilation defect percent (VDP) were previously reported for …

Analytical corrections for B1‐inhomogeneity and signal decay in multi‐slice 2D spiral hyperpolarized 129Xe MRI using keyhole reconstruction

JW Plummer, R Hussain, AS Bdaiwi… - Magnetic …, 2024 - Wiley Online Library
Purpose Hyperpolarized xenon MRI suffers from heterogeneous coil bias and magnetization
decay that obscure pulmonary abnormalities. Non‐physiological signal variability can be …

B1 and magnetization decay correction for hyperpolarized 129Xe lung imaging using sequential 2D spiral acquisitions

AS Bdaiwi, ML Costa, JW Plummer… - Magnetic …, 2023 - Wiley Online Library
Purpose To mitigate signal variations caused by inhomogeneous RF and magnetization
decay in hyperpolarized 129Xe ventilation images using flip‐angle maps generated from …

129Xe Image Processing Pipeline: An open‐source, graphical user interface application for the analysis of hyperpolarized 129Xe MRI

AS Bdaiwi, MM Willmering, JW Plummer… - Magnetic …, 2025 - Wiley Online Library
Abstract Purpose Hyperpolarized 129Xe MRI presents opportunities to assess regional
pulmonary microstructure and function. Ongoing advancements in hardware, sequences …

Evaluation of an integrated variable flip angle protocol to estimate coil B1 for hyperpolarized MRI

K Yeung, KL Ng, JJ McGing, A Axford… - Magnetic …, 2024 - Wiley Online Library
Purpose The purpose of this work is to validate a simple and versatile integrated variable flip
angle (VFA) method for mapping B1 in hyperpolarized MRI, which can be used to correct …

Hyperpolarized 129Xe MRI and spectroscopy of gas exchange abnormalities in chronic hypersensitivity pneumonitis

MK Wulfeck, DG Mummy, S Zhang, D Kadi, S Goins… - Respiratory …, 2024 - Elsevier
Purpose To evaluate 3D gas-exchange functional imaging characteristics using 129 Xe MRI
in a group of study participants with chronic hypersensitivity pneumonitis (CHP) as …

Functional gas exchange measures on 129Xe MRI and spectroscopy are associated with age, sex, and BMI in healthy subjects

D Mummy, S Zhang, A Bechtel, J Lu… - Frontiers in …, 2024 - frontiersin.org
Introduction Hyperpolarized 129Xe MRI and spectroscopy is a rapidly growing technique for
assessing lung function, with applications in a wide range of obstructive, restrictive, and …