BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

Bidirectional somatic cell–oocyte signaling is essential to create a changing intrafollicular
microenvironment that controls primordial follicle growth into a cohort of growing follicles …

Genetic predisposition to obesity presents a paradox: how do genetic variants with a
detrimental impact on human health persist through evolutionary time? Numerous …

Abstract BACKGROUND Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases
that catalyze post-translational modifications of proteins. Together, they respond to …

BACKGROUND The first small follicles to appear in the mammalian ovaries are primordial
follicles. The initial pool of primordial follicles serves as the source of developing follicles …

Premature ovarian failure (POF) is a refractory disease for clinical treatment with the goal of
restoring fertility. In this study, umbilical cord mesenchymal stem cells on a collagen scaffold …

Obesity, diabetes, and related metabolic disorders are major health issues worldwide. As
the epidemic of metabolic disorders continues, the associated medical co-morbidities …

The mitochondria, present in almost all eukaryotic cells, produce energy but also contribute
to many other essential cellular functions. One of the unique characteristics of the …

Mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase of the
phosphatidylinositol kinase-related kinase family that regulates cell growth, metabolism, and …

Increasing prevalence in obesity has become a significant public concern. C57BL/6J mice
are prone to diet-induced obesity (DIO) when fed high-fat diet (HFD), and develop chronic …