Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer, due to both its
late stage at diagnosis and its resistance to chemotherapy. However, recent advances in our …

A ubiquitously expressed cytokine, transforming growth factor-beta (TGF-β) plays a
significant role in various ongoing cellular mechanisms. The gain or loss-of-function of TGF …

Due to its poor prognosis and the late stage at which it is typically diagnosed, early detection
of pancreatic cancer is a pressing clinical problem. Advances in genomic analysis of human …

Whole chromosome and arm-level copy number alterations occur at high frequencies in
tumors, but their selective advantages, if any, are poorly understood. Here, utilizing …

Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis due to the lack
of methods or biomarkers for early diagnosis and its resistance to conventional treatment …

Pancreatic cancer arises from noninvasive precursor lesions, including pancreatic
intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), and …

Pancreatic intraepithelial neoplasias (PanINs) are the most common precursors of
pancreatic cancer, but their small size and inaccessibility in humans make them challenging …

In recent years, the paradigm that genomic abnormalities in cancer cells arise through
progressive accumulation of mutational events has been challenged by the discovery of …

Background The overall poor prognosis in pancreatic cancer is related to late clinical
detection. Early diagnosis remains a considerable challenge in pancreatic cancer …

Early detection of endometrial cancer, especially its precancers, remains a critical and
evolving issue in patient management and the quest to decrease mortality due to …