Restoration and targeting of aberrant neurotransmitters in Parkinson's disease therapeutics

D Yadav, P Kumar - Neurochemistry international, 2022 - Elsevier
Neurotransmitters are considered as a fundamental regulator in the process of neuronal
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …

Modulating role of serotonergic signaling in sleep and memory

S Vaseghi, S Arjmandi-Rad, M Eskandari… - Pharmacological …, 2022 - Springer
Serotonin is an important neurotransmitter with various receptors and wide-range effects on
physiological processes and cognitive functions including sleep, learning, and memory. In …

Serotonin/dopamine interaction: Electrophysiological and neurochemical evidence

P De Deurwaerdère, A Chagraoui… - Progress in brain …, 2021 - Elsevier
The interaction between serotonin (5-HT) and dopamine (DA) in the central nervous system
(CNS) plays an important role in the adaptive properties of living animals to their …

Activation and blockade of 5-HT4 receptors in the dorsal hippocampus enhance working and hippocampus-dependent memories in the unilateral 6-hydroxydopamine …

JW Wang, J Liu, ZL Wang, F Gao, J Yang… - Behavioural Brain …, 2022 - Elsevier
Cognitive dysfunction is a common symptom in Parkinson's disease (PD). Serotonin4 (5-HT
4) receptors are richly expressed in the dorsal hippocampus (dHIPP) and play an important …

Substantia nigra iron affects functional connectivity networks modifying working memory performance in younger adults

J Xu, X Guan, J Wen, T Wang… - European Journal of …, 2021 - Wiley Online Library
Brain iron affects working memory (WM) but the impact of iron content in deep grey matter
nuclei on WM networks is unknown. We aimed to test whether deep grey matter nuclei iron …

Activation of 5-HT1 receptor in lateral habenula impaired contextual fear memory and hippocampal LTP in rat

J Gu, Z Hou, X Zhou, Q Wang, Y Chen, J Zhang - Neuroscience Letters, 2022 - Elsevier
Abstract Serotonin (5-hydroxytraptamine, 5-HT) is a neurotransmitter plays important roles in
emotion and motivation. The action of 5-HT varies across nucleus and the receptor sub …

Serotonin1A receptors in the dorsal hippocampus regulate working memory and long-term habituation in the hemiparkinsonian rats

Y Liu, J Liu, SR Jiao, X Liu, Y Guo, J Zhang… - Behavioural Brain …, 2019 - Elsevier
Although the dorsal hippocampus (dHPC) and serotonin 1A (5-HT 1A) receptor are involved
in cognition, their roles in cognitive impairments in Parkinson'disease (PD) are still unclear …

The emerging role of LHb CaMKII in the comorbidity of depressive and alcohol use disorders

C Shor, W Zuo, JD Eloy, JH Ye - International journal of molecular …, 2020 - mdpi.com
Depressive disorders and alcohol use disorders are widespread among the general
population and are significant public health and economic burdens. Alcohol use disorders …

The Role of the Serotonergic System of the Brain in the Pathogenesis of Parkinson's Disease

A Goyal, W Chisti, A Verma, N Agrawal, K Bansal - Neurochemical Journal, 2023 - Springer
The traditional view of Parkinson's disease (PD) relies on dopamine depletion in the
striatum. However, PD is a multi-systemic disease that affects extra-dopaminergic systems …

Kv7. 2 subunit-containing M-type potassium channels in the lateral habenula are involved in the regulation of working memory in parkinsonian rats

G Bian, J Liu, Y Guo, Y Yang, L Li, H Qiao, W Li, T Xu… - …, 2020 - Elsevier
Although the lateral habenula (LHb) is involved in the regulation of multiple brain functions
and this region expresses abundant M-type potassium channel (M-channel) subunits Kv7. 2 …