Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the isoenzymes COX-1 and COX-2 of
cyclooxygenase (COX). Renal side effects (eg, kidney function, fluid and urinary electrolyte …

Simple Summary Diclofenac is a widely used drug for its anti-inflammatory and pain
alleviating properties. This review summarizes the current understanding about the drug …

Background Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) with anti-
inflammatory, analgestic, and antipyretic properties. It is approved for the treatment of …

There are at least two good reasons for the on-going interest in drug–target interactions: first,
drug-effects can only be fully understood by considering a complex network of interactions to …

Safety pharmacology studies that evaluate new drug entities for potential cardiac liability
remain a critical component of drug development. Current studies have shown that in vitro …

Aortic dissection (AD) is a life-threatening disease featured by the dissection of intimal layer
and the formation of a blood-filled false lumen within the aortic wall. Recent studies revealed …

Nine anthocyanins (1–9) from the edible fruits of Eugenia brasiliensis were identified by
HPLC-PDA and LC–MS, and seven of these are described for the first time in this Brazilian …

Despite the identification of molecular mechanisms associated with pain persistence, no
significant therapeutic improvements have been made. Advances in the understanding of …

Tumor metastases that impede the function of vital organs are a major cause of cancer
related mortality. Mitochondrial oxidative stress induced by hypoxia, low nutrient levels, or …

Although aspirin-exacerbated respiratory disease (AERD) has attracted a great deal of
attention because of its association with severe asthma, it remains widely under-diagnosed …