The quest for alternative drugs to the well-known cisplatin and its derivatives, which are still
used in more than 50% of the treatment regimes for patients suffering from cancer, is highly …

A novel strategy in metallodrug discovery today is incorporating clinically approved drugs
into metal complexes as coordinating ligands. Using this strategy, various drugs have been …

Neutral or cationic arene ruthenium complexes providing both hydrophilic as well as
hydrophobic properties due to the robustness of the ruthenium–arene unit hold a high …

Chloroquine (CQ), N′-(7-chloroquinolin-4-yl)-N, N-diethyl-pentane-1, 4-diamine, is widely
used as an effective and safe anti-malarial and anti-rheumatoid agent. CQ was discovered …

The successful clinical translation of platinum drugs for cancer treatment has witnessed an
upsurge in the development of metal compounds as therapeutics and diagnostics drugs …

The successful clinical application of the three generation platinum anticancer drugs,
cisplatin, carboplatin and oxaliplatin, has promoted research interest in metallodrugs; …

Late-stage modification of drug molecules is a fast method to introduce diversity into the
already biologically active scaffold. A notable number of analogs of mefloquine, chloroquine …

The introduction of multifunctionalities for tumour targeting is becoming a popular strategy
toward the development of new therapeutic agents. In particular, the multifaceted potential of …

Resistance to chemotherapy is a current clinical problem, especially in the treatment of
microbial infections and cancer. One strategy to overcome this is to make new derivatives of …

Tropical diseases today constitute a major health problem and a big challenge for drug
discovery. Because of the limited arsenal of effective antiparasitic agents and the frequent …