The immunology of macrophage activation syndrome

CB Crayne, S Albeituni, KE Nichols… - Frontiers in …, 2019 - frontiersin.org
Synonymous with secondary hemophagocytic lymphohistiocytosis, macrophage activation
syndrome (MAS) is a term used by rheumatologists to describe a potentially life-threatening …

Cytokine storm syndrome

RQ Cron, G Goyal, WW Chatham - Annual Review of Medicine, 2023 - annualreviews.org
Cytokine storm syndrome (CSS), which is frequently fatal, has garnered increased attention
with the ongoing coronavirus pandemic. A variety of hyperinflammatory conditions …

Benefit of anakinra in treating pediatric secondary hemophagocytic lymphohistiocytosis

EM Eloseily, P Weiser, CB Crayne… - Arthritis & …, 2020 - Wiley Online Library
Objective To assess the benefit of the recombinant human interleukin‐1 receptor antagonist
anakinra in treating pediatric patients with secondary hemophagocytic lymphohistiocytosis …

2016 classification criteria for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: a European League Against Rheumatism/American …

A Ravelli, F Minoia, S Davì, AC Horne… - Arthritis & …, 2016 - Wiley Online Library
Objective To develop criteria for the classification of macrophage activation syndrome (MAS)
in patients with systemic juvenile idiopathic arthritis (JIA). Methods A multistep process …

Macrophage activation syndrome in adults: recent advances in pathophysiology, diagnosis and treatment

SJ Carter, RS Tattersall, AV Ramanan - Rheumatology, 2019 - academic.oup.com
Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome, which if not
promptly treated, can lead rapidly to critical illness and death. HLH is termed macrophage …

Inhibition of natural killer cell cytotoxicity by interleukin‐6: implications for the pathogenesis of macrophage activation syndrome

L Cifaldi, G Prencipe, I Caiello… - Arthritis & …, 2015 - Wiley Online Library
Objective Systemic juvenile idiopathic arthritis (JIA) is associated with high levels of
interleukin‐6 (IL‐6) in the serum and synovial fluid, and impairment of natural killer (NK) cell …

The cytokine storms of COVID-19, H1N1 influenza, CRS and MAS compared. Can one sized treatment fit all?

G Morris, CC Bortolasci, BK Puri, W Marx, A O'Neil… - Cytokine, 2021 - Elsevier
An analysis of published data appertaining to the cytokine storms of COVID-19, H1N1
influenza, cytokine release syndrome (CRS), and macrophage activation syndrome (MAS) …

Macrophage activation syndrome and secondary hemophagocytic lymphohistiocytosis in childhood inflammatory disorders: diagnosis and management

LA Henderson, RQ Cron - Pediatric Drugs, 2020 - Springer
Macrophage activation syndrome (MAS), a form of secondary hemophagocytic
lymphohistiocytosis, is a frequently fatal complication of a variety of pediatric inflammatory …

Macrophage polarization and plasticity in systemic lupus erythematosus

MM Ahamada, Y Jia, X Wu - Frontiers in immunology, 2021 - frontiersin.org
Systemic lupus erythematosus (SLE) is an autoimmune disease that attacks almost every
organ. The condition mostly happens to adults but is also found in children, and the latter …

Macrophage activation syndrome: different mechanisms leading to a one clinical syndrome

C Bracaglia, G Prencipe, F De Benedetti - Pediatric Rheumatology, 2017 - Springer
Background Macrophage activation syndrome (MAS) is a severe complication of rheumatic
disease in childhood, particularly in systemic Juvenile Idiopathic Arthritis (sJIA). It is …