The comet assay in animal models: From bugs to whales–(Part 2 Vertebrates)
The comet assay has become one of the methods of choice for the evaluation and
measurement of DNA damage. It is sensitive, quick to perform and relatively affordable for …
measurement of DNA damage. It is sensitive, quick to perform and relatively affordable for …
Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways
WW Lai, SC Hsu, FS Chueh, YY Chen… - Anticancer …, 2013 - ar.iiarjournals.org
Quercetin, a principal flavanoid compound in onions, has been shown to possess a wide
spectrum of pharmacological properties, including anticancer activities. Our earlier study …
spectrum of pharmacological properties, including anticancer activities. Our earlier study …
The development of bis (hydroxymethyl) pyrrole analogs as bifunctional DNA cross-linking agents and their chemotherapeutic potential
TL Su, TC Lee, R Kakadiya - European Journal of Medicinal Chemistry, 2013 - Elsevier
Bifunctional DNA cross-linking agents are widely used as chemotherapeutic agents in
clinics. The advance in the development of these agents as potential antitumor agents has …
clinics. The advance in the development of these agents as potential antitumor agents has …
Silencing JARID1B suppresses oncogenicity, stemness and increases radiation sensitivity in human oral carcinoma
CS Lin, YC Lin, BO Adebayo, A Wu, JH Chen, YJ Peng… - Cancer letters, 2015 - Elsevier
Purpose Oral squamous cell carcinoma (OSCC) is a major cause of human mortality
globally and radiotherapy is one of the main treatment modalities, however its therapeutic …
globally and radiotherapy is one of the main treatment modalities, however its therapeutic …
Depleting IFIT2 mediates atypical PKC signaling to enhance the migration and metastatic activity of oral squamous cell carcinoma cells
Interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) is one of the most highly
responsive interferon-stimulated genes, but its biological functions are poorly understood. In …
responsive interferon-stimulated genes, but its biological functions are poorly understood. In …
Paxillin promotes tumor progression and predicts survival and relapse in oral cavity squamous cell carcinoma by microRNA-218 targeting
DW Wu, CY Chuang, WL Lin, WW Sung… - …, 2014 - academic.oup.com
High-risk human papillomavirus (HPV) 16-infected oral cavity squamous cell carcinoma
(OCSCC) differs significantly from non-HPV-infected OCSCC. However, the molecular …
(OCSCC) differs significantly from non-HPV-infected OCSCC. However, the molecular …
Tetrandrine induces programmed cell death in human oral cancer CAL 27 cells through the reactive oxygen species production and caspase‐dependent pathways …
Tetrandrine, a bisbenzylisoquinoline alkaloid, is extracted from the root of the Chinese herb
Radix Stephania tetrandra S Moore. This compound has antitumor activity in different cancer …
Radix Stephania tetrandra S Moore. This compound has antitumor activity in different cancer …
Triggering Apoptotic Death of Human Malignant Melanoma A375. S2 Cells by Bufalin: Involvement of Caspase Cascade‐Dependent and Independent Mitochondrial …
YP Hsiao, CS Yu, CC Yu, JS Yang… - Evidence‐Based …, 2012 - Wiley Online Library
Bufalin was obtained from the skin and parotid venom glands of toad and has been shown
to induce cytotoxic effects in various types of cancer cell lines, but there is no report to show …
to induce cytotoxic effects in various types of cancer cell lines, but there is no report to show …
Cell death caused by quinazolinone HMJ-38 challenge in oral carcinoma CAL 27 cells: Dissections of endoplasmic reticulum stress, mitochondrial dysfunction and …
Background This investigation clearly clarified the synthesized and antimitotic compound, 2-
(3′-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone (HMJ-38), addressing its target and …
(3′-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone (HMJ-38), addressing its target and …
AKT serine/threonine protein kinase modulates bufalin-triggered intrinsic pathway of apoptosis in CAL 27 human oral cancer cells
SC Tsai, CC Lu, CY Lee, YC Lin… - International …, 2012 - spandidos-publications.com
Bufalin has been reported to induce apoptosis in a variety of cancers but little is
demonstrated in oral squamous cell carcinoma (OSCC) cells. The present study investigated …
demonstrated in oral squamous cell carcinoma (OSCC) cells. The present study investigated …