Recent developments in genomics, bioinformatics, proteomics, and analytical techniques
have resulted in a more detailed and thorough understanding of the structure of the …

Isoprenoid biosynthesis is essential for cell survival. Over 35 000 isoprenoid molecules have
been identified to date in the three domains of life (bacteria, archaea and eukaryotes), and …

The 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway leads to the biosynthesis of
isopentenyl diphosphate (IDP) and dimethylallyl diphosphate (DMADP), the precursors for …

Grape berries of Muscat cultivars (Vitis vinifera L.) contain high levels of monoterpenols and
exhibit a distinct aroma related to this composition of volatiles. A structural gene of the …

The recent determination of the complete genome sequence of Corynebacterium
diphtheriae, the aetiological agent of diphtheria, has allowed a detailed comparison of its …

The compositional and architectural complexity of the mycobacterial cell envelope is
probably the most distinctive feature of the Mycobacterium genus. It is the basis of many of …

Using a conditional mutagenesis strategy we demonstrate here that a gene cluster encoding
putative aminoarabinose (Ara4N) biosynthesis enzymes is essential for the viability of …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a severe infectious
disease in need of new chemotherapies especially for drug-resistant cases. To meet the …

Deoxy-d-xylulose 5-phosphate reductoisomerase (IspC) catalyzes the first committed step in
the mevalonate-independent isopentenyl diphosphate biosynthetic pathway and is a …

Emerging resistance of human pathogens to anti-infective agents make it necessary to
develop new agents to treat infection. The methylerythritol phosphate pathway has been …