Phase separation in biology; functional organization of a higher order
DM Mitrea, RW Kriwacki - Cell Communication and Signaling, 2016 - Springer
Inside eukaryotic cells, macromolecules are partitioned into membrane-bounded
compartments and, within these, some are further organized into non-membrane-bounded …
compartments and, within these, some are further organized into non-membrane-bounded …
Shikonin derivatives for cancer prevention and therapy
Phytochemicals gained considerable interest during the past years as source to develop
new treatment options for chemoprevention and cancer therapy. Motivated by the fact that a …
new treatment options for chemoprevention and cancer therapy. Motivated by the fact that a …
Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA
The nucleolus is a membrane-less organelle formed through liquid-liquid phase separation
of its components from the surrounding nucleoplasm. Here, we show that nucleophosmin …
of its components from the surrounding nucleoplasm. Here, we show that nucleophosmin …
Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity
Z Tao, H Wang, Q Xia, K Li, K Li, X Jiang… - Human molecular …, 2015 - academic.oup.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are the two common
neurodegenerative diseases that have been associated with the GGGGCC· GGCCCC …
neurodegenerative diseases that have been associated with the GGGGCC· GGCCCC …
Nucleolus: a central hub for nuclear functions
The nucleolus is the largest and most studied nuclear body, but its role in nuclear function is
far from being comprehensively understood. Much work on the nucleolus has focused on its …
far from being comprehensively understood. Much work on the nucleolus has focused on its …
NPM1/B23: a multifunctional chaperone in ribosome biogenesis and chromatin remodeling
MS Lindström - Biochemistry research international, 2011 - Wiley Online Library
At a first glance, ribosome biogenesis and chromatin remodeling are quite different
processes, but they share a common problem involving interactions between charged …
processes, but they share a common problem involving interactions between charged …
Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases
E Colombo, M Alcalay, PG Pelicci - Oncogene, 2011 - nature.com
Nucleophosmin (NPM, also known as B23, numatrin or NO38) is a ubiquitously expressed
phosphoprotein belonging to the nucleoplasmin family of chaperones. NPM is mainly …
phosphoprotein belonging to the nucleoplasmin family of chaperones. NPM is mainly …
The nucleolus: a central response hub for the stressors that drive cancer progression
SE Weeks, BJ Metge, RS Samant - Cellular and Molecular Life Sciences, 2019 - Springer
The nucleolus is a sub-nuclear body known primarily for its role in ribosome biogenesis.
Increased number and/or size of nucleoli have historically been used by pathologists as a …
Increased number and/or size of nucleoli have historically been used by pathologists as a …
A redox mechanism underlying nucleolar stress sensing by nucleophosmin
The nucleolus has been recently described as a stress sensor. The nucleoplasmic
translocation of nucleolar protein nucleophosmin (NPM1) is a hallmark of nucleolar stress; …
translocation of nucleolar protein nucleophosmin (NPM1) is a hallmark of nucleolar stress; …
Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid–liquid phase separation
K González-Arzola, A Díaz-Quintana… - Nature structural & …, 2022 - nature.com
The regular functioning of the nucleolus and nucleus-mitochondria crosstalk are considered
unrelated processes, yet cytochrome c (C c) migrates to the nucleus and even the nucleolus …
unrelated processes, yet cytochrome c (C c) migrates to the nucleus and even the nucleolus …