Small cells–big issues: biological implications and preclinical advancements in small cell lung cancer

A Solta, B Ernhofer, K Boettiger, Z Megyesfalvi… - Molecular cancer, 2024 - Springer
Current treatment guidelines refer to small cell lung cancer (SCLC), one of the deadliest
human malignancies, as a homogeneous disease. Accordingly, SCLC therapy comprises …

Rictor—a mediator of progression and metastasis in lung cancer

F Szalai, D Sztankovics, I Krencz, D Moldvai, J Pápay… - Cancers, 2024 - mdpi.com
Simple Summary Despite recent advances in targeted therapy and immunotherapy, the
treatment of lung cancer remains challenging due to its high metastatic potential, which …

[HTML][HTML] Longitudinal detection of subcategorized CD44v6+ CTCs and circulating tumor endothelial cells (CTECs) enables novel clinical stratification and improves …

Y Wang, L Zhang, J Tan, Z Zhang, Y Liu, X Hu, B Lu… - Cancer Letters, 2023 - Elsevier
Current management of small cell lung cancer (SCLC) remains challenging. Effective
biomarkers are needed to subdivide patients presenting distinct treatment response and …

Targeting immune cell types of tumor microenvironment to overcome resistance to PD-1/PD-L1 blockade in lung cancer

M Wang, L Zhu, X Yang, J Li, Y Liu… - Frontiers in …, 2023 - frontiersin.org
Lung cancer is the common malignant tumor with the highest mortality rate. Lung cancer
patients have achieved benefits from immunotherapy, including immune checkpoint …

Immunotherapy in Combination with Chemotherapy for Triple-negative Breast Cancer

MS Elizabeth, CG Christian - Mini Reviews in Medicinal …, 2024 - ingentaconnect.com
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks
estrogen and progesterone receptors and does not overexpress the human epidermal …

Abnormal expression of Krüppel-like transcription factors and their potential values in lung cancer

Y Shi, M Yao, S Shen, L Wang, D Yao - Heliyon, 2024 - cell.com
Lung cancer still is one of the most common malignancy tumors in the world. However, the
mechanisms of its occurrence and development have not been fully elucidated. Zinc finger …

[HTML][HTML] Disseminated tumor cells in bone marrow as predictive classifiers for small cell lung cancer patients

Y Wang, J Nong, B Lu, Y Gao, M Hu, C Chen… - Journal of the National …, 2024 - Elsevier
Background Small cell lung cancer (SCLC) is a highly aggressive disease characterized by
early metastasis. Aneuploid CD31-disseminated tumor cells (DTCs) and CD31+ …

Efficacy and safety of novel immune checkpoint inhibitor‐based combinations versus chemotherapy as first‐line treatment for patients with extensive‐stage small cell …

C Yang, T Xuan, Q Gong, X Dai, C Wang… - Thoracic …, 2024 - Wiley Online Library
Background Patients with extensive‐stage small cell lung cancer (ES‐SCLC) have an
exceptionally poor prognosis and immune checkpoint inhibitors (ICIs) combined with …

EBV-positive small cell neuroendocrine carcinoma of nasopharynx as a probably unique subtype of neuroendocrine carcinoma: a clinicopathologic study of three …

Y Chen, N Zhou, C Huang, X He, X Wang, H Tang… - Diagnostic …, 2024 - Springer
There is currently scarcity of information on small cell neuroendocrine carcinoma of the
nasopharynx (SCNEC-nasopharynx). It is believed that this type of cancer is not associated …

Fifteen years of precision medicine in the lung cancer management: Perspectives and Challenges

CG Ferreira, P De Marchi, GGV Veloso… - Medical Research …, 2024 - esmed.org
Precision medicine has revolutionized lung cancer management–particularly non-
squamous cell carcinomas–with a broader genomic comprehension and the possibility of …