Actions of brain-derived neurotrophin factor in the neurogenesis and neuronal function, and its involvement in the pathophysiology of brain diseases

T Numakawa, H Odaka, N Adachi - International journal of molecular …, 2018 - mdpi.com
It is well known that brain-derived neurotrophic factor, BDNF, has an important role in a
variety of neuronal aspects, such as differentiation, maturation, and synaptic function in the …

[HTML][HTML] The role of serotonin within the microbiota-gut-brain axis in the development of Alzheimer's disease: A narrative review

E Aaldijk, Y Vermeiren - Ageing Research Reviews, 2022 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia, accounting for more than
50 million patients worldwide. Current evidence suggests the exact mechanism behind this …

[HTML][HTML] MDMA-assisted psychotherapy for PTSD: growing evidence for memory effects mediating treatment efficacy

M Sarmanlu, KPC Kuypers, P Vizeli… - Progress in Neuro …, 2024 - Elsevier
The application of MDMA in conjunction with psychotherapy has in recent years seen a
resurgence of clinical, scientific, and public interest in the treatment of posttraumatic stress …

Serotonin 2A receptors are a stress response system: implications for post-traumatic stress disorder

KS Murnane - Behavioural pharmacology, 2019 - journals.lww.com
Serotonin, one of the first neurotransmitters to be identified, is an evolutionarily old molecule
that is highly conserved across the animal kingdom, and widely used throughout the brain …

[HTML][HTML] Biased agonism in drug discovery: Is there a future for biased 5-HT1A receptor agonists in the treatment of neuropsychiatric diseases?

K Sałaciak, K Pytka - Pharmacology & Therapeutics, 2021 - Elsevier
Abstract Serotonin (5-HT) is one of the fundamental neurotransmitters that contribute to the
information essential for an organism's normal, physiological function. Serotonin acts …

The role of serotonin neurotransmission in rapid antidepressant actions

AL Pehrson, D Roberts, A Khawaja, R McNair - Psychopharmacology, 2022 - Springer
Rationale Ketamine has rapid antidepressant effects that represent a significant advance in
treating depression, but its poor safety and tolerability limit its clinical utility. Accreting …

Modulating role of serotonergic signaling in sleep and memory

S Vaseghi, S Arjmandi-Rad, M Eskandari… - Pharmacological …, 2022 - Springer
Serotonin is an important neurotransmitter with various receptors and wide-range effects on
physiological processes and cognitive functions including sleep, learning, and memory. In …

Understanding how physical exercise improves Alzheimer's disease: cholinergic and monoaminergic systems

B Zong, F Yu, X Zhang, W Zhao, P Sun… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is an age-related neurodegenerative disorder, characterized by
the accumulation of proteinaceous aggregates and neurofibrillary lesions composed of β …

Geraniol improves passive avoidance memory and hippocampal synaptic plasticity deficits in a rat model of Alzheimer's disease

S Bagheri, M Rashno, I Salehi, SA Karimi… - European Journal of …, 2023 - Elsevier
Alzheimer's disease (AD) is the most progressive and irreversible neurodegenerative
disease that leads to synaptic loss and cognitive decline. The present study was designed to …

The Chronic Treatment With 5-HT2A Receptor Agonists Affects the Behavior and the BDNF System in Mice

AS Tsybko, TV Ilchibaeva, EA Filimonova… - Neurochemical …, 2020 - Springer
Serotonin 5-HT 2A receptors and the brain-derived neurotrophic factor (BDNF) are involved
in the pathophysiology and treatment of many psychiatric diseases. However, the interaction …