Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …

Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

NF-κB-inducing kinase (NIK), the essential upstream kinase, which regulates activation of
the noncanonical NF-κB pathway, has important roles in regulating immunity and …

Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and
metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby …

Ovarian cancer is the most lethal gynecologic malignancy in the United States, with an
estimated 22,530 new cases and 13,980 deaths in 2019. Recent studies have indicated that …

Ovarian cancer (OC) is the most lethal gynecological malignancy due to tumor
heterogeneity, the lack of reliable early diagnosis methods and the high incidence of …

The NF-κB signaling pathway is a master and commander in ovarian cancer (OC) that
promotes chemoresistance, cancer stem cell maintenance, metastasis and immune evasion …

Cancer stem cells (CSCs) account for tumor initiation, invasiveness, metastasis, and
recurrence in a broad range of human cancers. Although being a key player in cancer …

The concept of a “cancer stem cell” has evolved over the past decades, and research on
cancer stem cell biology has entered into a stage of remarkable progress. Cancer stem cells …