The recently discovered endogenous opioid peptides, endomorphins-1 and-2, appear to
have properties consistent with neurotransmitter/neuromodulator actions in mammals. This …

Experimental evidence indicates that cannabidiol (CBD) induces anxiolytic and antiepileptic
effects through the activation of 5-HT1A receptors. These receptors are coupled to Gi/o …

The catabolism of the endomorphins was investigated in detail. The endomorphins were
degraded relatively slowly in the rat brain homogenate (t1/2 (endomorphin-1)= 4.94 min; t1/2 …

Centrally acting plant opiates, such as morphine, are the most frequently used analgesics for
the relief of severe pain, even though their undesired side effects are serious limitation to …

In this paper, we describe the synthesis of novel endomorphin-2 analogs, containing N-
methylated amino acids, consecutively in each position. The receptor-binding profile of the …

Endomorphins were subjected to a number of structural modifications in a search for their
bioactive conformations. The alicyclic β-amino acids cis-(1 S, 2 R) ACPC/ACHC, cis-(1 R, 2 …

Recent statistics from the World Health Organization indicate that a high percentage of
people worldwide suffer from a wide variety of acute or cancer‐associated chronic pain. At …

The recently discovered native endomorphins play an important role in opioid analgesia, but
their metabolic fate in the organism remains relatively little known. This paper describes the …

Endomorphins-1 and-2 were substituted with all the β-MePhe stereoisomers in their Phe
residues to generate a conformationally constrained peptide set. This series of molecules …

The recently discovered endomorphin 1 (Tyr‐Pro‐Trp‐Phe‐NH2) and endomorphin 2 (Tyr‐
Pro‐Phe‐Phe‐NH2) were investigated with respect to their direct receptor‐binding …