Recent decades have been marked by enormous progress in the field of synthesis and
chemistry of 5‐(hydroxymethyl) furfural (HMF), an important platform chemical widely …

The European Lead Factory (ELF) is a public–private partnership (PPP) that provides
researchers in Europe with a unique platform for translation of innovative biology and …

Many compound collections used in high-throughput screening are composed of members
whose structural complexity is considerably lower than that of natural products. We …

Structurally complex natural products have been a fruitful source for the discovery and
development of new drugs. In an effort to construct a compound collection populated by …

We present a new and straightforward one-pot process for the synthesis of 3-carbonyl-4-
quinolone derivatives through highly efficient Cu-catalyzed aza-Michael addition of 2 …

A unified synthetic approach was developed that enabled the synthesis of diverse tropane-
related scaffolds. The key intermediates that were exploited were cycloadducts formed by …

2-Bromo-1, 3-butadienes are demonstrated to be effective substrates for tandem Diels–
Alder/transition metal cross-coupling reaction sequences. Intermolecular cycloaddition of a 2 …

Highlights•Partnership translated academic chemistry into screening libraries.•Many
molecular scaffolds were sp 3-rich and natural-product-like.•A blueprint for exploiting …

The species-rich genus Palicourea (Rubiaceae: Palicoureeae) is source of an intriguing
diversity of alkaloids derived from tryptamine and its precursor tryptophan. So far simple …

A series of 1, 4: 5, 8-diepoxynaphthalenes, annellated with six-membered carbo-and
heterocycles, was obtained via the intramolecular Diels–Alder furan (IMDAF) cycloaddition …