Neuroblastoma pathogenesis: deregulation of embryonic neural crest development
Neuroblastoma (NB) is an aggressive pediatric cancer that originates from neural crest
tissues of the sympathetic nervous system. NB is highly heterogeneous both from a clinical …
tissues of the sympathetic nervous system. NB is highly heterogeneous both from a clinical …
[HTML][HTML] Stability of the hybrid epithelial/mesenchymal phenotype
Abstract Epithelial-to-Mesenchymal Transition (EMT) and its reverse–Mesenchymal to
Epithelial Transition (MET)–are hallmarks of cellular plasticity during embryonic …
Epithelial Transition (MET)–are hallmarks of cellular plasticity during embryonic …
Recent discoveries concerning the involvement of transcription factors from the Grainyhead-like family in cancer
M Mlacki, A Kikulska, E Krzywinska… - Experimental …, 2015 - journals.sagepub.com
The Grainyhead-like (GRHL) family of transcription factors has three mammalian members,
which are currently termed Grainyhead-like 1 (GRHL1), Grainyhead-like 2 (GRHL2), and …
which are currently termed Grainyhead-like 1 (GRHL1), Grainyhead-like 2 (GRHL2), and …
GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification
Abstract Epithelial-mesenchymal transition (EMT), a biological process by which polarized
epithelial cells convert into a mesenchymal phenotype, has been implicated to contribute to …
epithelial cells convert into a mesenchymal phenotype, has been implicated to contribute to …
Dual roles of the transcription factor grainyhead-like 2 (GRHL2) in breast cancer
Using a retrovirus-mediated cDNA expression cloning approach, we identified the
grainyhead-like 2 (GRHL2) transcription factor as novel protooncogene. Overexpression of …
grainyhead-like 2 (GRHL2) transcription factor as novel protooncogene. Overexpression of …
Grhl2 reduces invasion and migration through inhibition of TGFβ-induced EMT in gastric cancer
J Xiang, X Fu, W Ran, Z Wang - Oncogenesis, 2017 - nature.com
Metastasis is one of the typical features of malignancy that significantly increases cancer-
related mortality. Recent studies have shown that epithelial–mesenchymal transition (EMT) …
related mortality. Recent studies have shown that epithelial–mesenchymal transition (EMT) …
[HTML][HTML] Grainyhead-like 2 promotes tumor growth and is associated with poor prognosis in colorectal cancer
Y Quan, M Xu, P Cui, M Ye, B Zhuang, Z Min - Journal of Cancer, 2015 - ncbi.nlm.nih.gov
GRHL2 was implicated in regulating cancer development. Our previous study demonstrated
that knockdown GRHL2 in colorectal cancer (CRC) cells inhibited cell proliferation by …
that knockdown GRHL2 in colorectal cancer (CRC) cells inhibited cell proliferation by …
Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family
Q Ming, Y Roske, A Schuetz, K Walentin… - Nucleic acids …, 2018 - academic.oup.com
Abstract Grainyhead (Grh)/CP2 transcription factors are highly conserved in multicellular
organisms as key regulators of epithelial differentiation, organ development and skin barrier …
organisms as key regulators of epithelial differentiation, organ development and skin barrier …
GRHL2-controlled gene expression networks in luminal breast cancer
Z Wang, B Coban, H Wu, J Chouaref… - Cell Communication and …, 2023 - Springer
Abstract Grainyhead like 2 (GRHL2) is an essential transcription factor for development and
function of epithelial tissues. It has dual roles in cancer by supporting tumor growth while …
function of epithelial tissues. It has dual roles in cancer by supporting tumor growth while …