The blood-brain barrier: Physiology and strategies for drug delivery
The blood-brain barrier (BBB) is a dynamic structure that functions as a gatekeeper,
reflecting the unique requirements of the brain. In this review, following a brief historical …
reflecting the unique requirements of the brain. In this review, following a brief historical …
Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery
Apart from its clinical use in imaging, ultrasound has been thoroughly investigated as a tool
to enhance drug delivery in a wide variety of applications. Therapeutic ultrasound, as such …
to enhance drug delivery in a wide variety of applications. Therapeutic ultrasound, as such …
Ultrasound as a versatile tool for short-and long-term improvement and monitoring of brain function
DG Blackmore, D Razansky, J Götz - Neuron, 2023 - cell.com
Treating the brain with focused ultrasound (FUS) at low intensities elicits diverse responses
in neurons, astroglia, and the extracellular matrix. In combination with intravenously injected …
in neurons, astroglia, and the extracellular matrix. In combination with intravenously injected …
Safety evaluation of a clinical focused ultrasound system for neuronavigation guided blood-brain barrier opening in non-human primates
An emerging approach with potential in improving the treatment of neurodegenerative
diseases and brain tumors is the use of focused ultrasound (FUS) to bypass the blood–brain …
diseases and brain tumors is the use of focused ultrasound (FUS) to bypass the blood–brain …
Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer's disease
Preclinical and clinical data support the use of focused ultrasound (FUS), in the presence of
intravenously injected microbubbles, to safely and transiently increase the permeability of …
intravenously injected microbubbles, to safely and transiently increase the permeability of …
[HTML][HTML] Repeated ultrasound treatment of tau transgenic mice clears neuronal tau by autophagy and improves behavioral functions
Intracellular deposits of pathological tau are the hallmark of a broad spectrum of
neurodegenerative disorders collectively known as tauopathies, with Alzheimer's disease, a …
neurodegenerative disorders collectively known as tauopathies, with Alzheimer's disease, a …
Secondary effects on brain physiology caused by focused ultrasound-mediated disruption of the blood–brain barrier
Focused ultrasound (FUS) combined with microbubbles is a non-invasive method for
targeted, reversible disruption of the blood–brain barrier (FUS-BBB opening). This approach …
targeted, reversible disruption of the blood–brain barrier (FUS-BBB opening). This approach …
[HTML][HTML] Role for caveolin-mediated transcytosis in facilitating transport of large cargoes into the brain via ultrasound
R Pandit, WK Koh, RKP Sullivan, T Palliyaguru… - Journal of Controlled …, 2020 - Elsevier
The blood-brain barrier (BBB) is a dynamic diffusional barrier regulating the molecular and
chemical flux between the blood and brain, thereby preserving cerebral homeostasis …
chemical flux between the blood and brain, thereby preserving cerebral homeostasis …
Recent advances on ultrasound contrast agents for blood-brain barrier opening with focused ultrasound
The blood-brain barrier is the primary obstacle to efficient intracerebral drug delivery.
Focused ultrasound, in conjunction with microbubbles, is a targeted and non-invasive way to …
Focused ultrasound, in conjunction with microbubbles, is a targeted and non-invasive way to …
Clinical relevance of animal models in aging-related dementia research
P Padmanabhan, J Götz - Nature Aging, 2023 - nature.com
Alzheimer's disease (AD) and other, less prevalent dementias are complex age-related
disorders that exhibit multiple etiologies. Over the past decades, animal models have …
disorders that exhibit multiple etiologies. Over the past decades, animal models have …