Reducing background signal and improving detection sensitivity is one of the main research
directions of optical biosensors. Based on the structure and functional characteristics of …

Molecular profiling based on genomic mutations provides clinically important diagnostic and
prognostic information. Companion diagnostic (CDx) testing, which is based on targeted …

Rapid analysis of cytology samples obtained by minimally invasive sampling is essential in
clinical diagnosis, yet existing diagnostic methods are often cumbersome and time …

Although molecular profiling of DNA isolated from formalin-fixed, paraffin-embedded (FFPE)
tumor specimens has become more common in recent years, it remains unclear how …

The type of fixative used for preserving tumor specimens can significantly impact the
performance of the immunohistochemistry and in situ hybridization assays used for …

Objective Immunohistochemical expression of P53 protein is so closely related to status of
mutation of P53 gene which is tightly linked with pathogenesis of nephroblastoma or Wilms …

Antibodies targeting programmed death receptor 1 or programmed death ligand 1 (PD-L1)
have become a standard of care to treat different cancers; for some of these tumors, there is …

All cancers are different from each other, in their mutation spectrum, primary location of
occurrence, and metastases as well as their phenotypic traits and tumor composition. For …

Histochemistry of tumor sections is a widely employed technique utilized to examine cell
death in preclinical xenograft animal models of cancer. However, this is under the …

KNOWLEDGE – International Journal Vol.55.4 SIGNIFICANCE OF PRE-ANALYTICAL
PHASE IN PATHOHISTOLOGICAL DIAGNOSTIC PROCESS Q Page 1 KNOWLEDGE …