Short-chain dehydrogenases/reductases (SDRs) constitute a large family of NAD (P)(H)-
dependent oxidoreductases, sharing sequence motifs and displaying similar mechanisms …

The aldo-keto reductase (AKR) superfamily comprises enzymes that catalyze redox
transformations involved in biosynthesis, intermediary metabolism, and detoxification …

Short-chain dehydrogenases/reductases form a large, evolutionarily old family of NAD
(P)(H)-dependent enzymes with over 60 genes found in the human genome. Despite low …

Molecular recognition between proteins and their interacting partners underlies the
biochemistry of living organisms. Specificity in this recognition is thought to be essential …

Short-chain dehydrogenases/reductases (SDR) form a large, functionally heterogeneous
protein family presently with about 3000 primary and about 30 3D structures deposited in …

Short‐chain dehydrogenases/reductases (SDRs) are enzymes of great functional diversity.
Even at sequence identities of typically only 15–30%, specific sequence motifs are …

Steroids are complex lipophilic molecules that have many actions in the body to regulate
cellular, tissue and organ functions across the life-span. Steroid hormones such as cortisol …

The biological activity of steroid hormones is regulated at the pre-receptor level by several
enzymes including 17 beta-hydroxysteroid dehydrogenases (17 beta-HSD). The latter are …

To date, about 90 post-transcriptional modifications have been reported in tRNA expanding
their chemical and functional diversity. Methylation is the most frequent post-transcriptional …

The short‐chain dehydrogenase/reductase (SDR) superfamily now has over 47 000
members, most of which are distantly related, with typically 20–30% residue identity in …