Advances achieved with molecular biology and genomics technologies have permitted
investigators to discover epigenetic mechanisms, such as DNA methylation and histone …

Aging is a significant risk factor for Alzheimer's disease (AD), although the precise
mechanism and molecular basis of AD are not yet fully understood. Epigenetic mechanisms …

Epigenetic aberration is implicated in aging and neurodegeneration. Using postmortem
tissues from patients with Alzheimer's disease (AD) and AD mouse models, we have found …

Gene expression is tremendously altered in the brain during memory acquisition, recall, and
forgetfulness. However, non-genetic factors, including environmental elements, epigenetic …

One-carbon metabolism provides the methyl groups for both DNA and histone tail
methylation reactions, two of the main epigenetic processes that tightly regulate the …

Alzheimer's disease (AD) is the most common neurodegenerative disorder and there is
currently no cure. Neural circuit dysfunction is the fundamental mechanism underlying the …

Introduction: Alzheimer's disease (AD) is the most common neurodegenerative disorder and
the primary form of dementia in the elderly. Changes in DNA methylation and post …

Alzheimer's disease (AD) is a common chronic neurodegenerative disease characterized by
cognitive learning and memory impairments, however, current treatments only provide …

Alzheimer disease (AD) is a prevalent neurodegenerative disorder that affects synapses and
leads to progressive cognitive decline. The role of N-methyl-D-aspartic acid (NMDA) …

Protein lysine methyltransferases (PKMTs) methylate histone and non-histone proteins to
regulate biological outcomes such as development and disease including viral infection …