Aging is a major risk factor for a variety of diseases, thus, translation of aging research into
practical applications is driven by the unmet need for existing clinical therapeutic options …

Alzheimer's disease is a devastating neurodegenerative disorder that poses a significant
societal burden. Approval of anti-amyloid antibody therapies is a significant milestone for …

Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide
(NAD+) is involved in an extensive spectrum of human pathologies, including …

Nicotinamide mononucleotide (NMN), the direct precursor of nicotinamide adenine
dinucleotide (NAD+), is involved in the regulation of many physiological and metabolic …

NAD+ is crucial for cellular balance in all organisms. Recent interest has focused on its
metabolism. Deficiency-related issues can be countered using NMN and NR, potential …

Abstract SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), induces
vascular endothelial dysfunction, but the mechanisms are unknown. We tested the …

People with lower extremity peripheral artery disease (PAD) have increased oxidative
stress, impaired mitochondrial activity, and poor walking performance. NAD+ reduces …

Fatigue is a common symptom of rheumatic diseases and frequently persists even when
patients are in a near-remission state. In seeking options to manage troublesome symptoms …

Purpose The purpose of this study was to determine the effect of acute nicotinamide riboside
(NR) supplementation on cerebral nicotinamide adenine dinucleotide (NAD+) levels in the …

Cardiorenal diseases represent a complex interplay between heart failure and renal
dysfunction, being clinically classified as cardiorenal syndromes (CRS). Recently, the …