Congenital adrenal hyperplasia—current insights in pathophysiology, diagnostics, and management

HL Claahsen-van der Grinten, PW Speiser… - Endocrine …, 2022 - academic.oup.com
Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders affecting
cortisol biosynthesis. Reduced activity of an enzyme required for cortisol production leads to …

Sex differences are here to stay: relevance to prenatal care

AM Inkster, I Fernández-Boyano… - Journal of Clinical …, 2021 - mdpi.com
Sex differences exist in the incidence and presentation of many pregnancy complications,
including but not limited to pregnancy loss, spontaneous preterm birth, and fetal growth …

Cognitive functions in children at risk for congenital adrenal hyperplasia treated prenatally with dexamethasone

T Hirvikoski, A Nordenstrom, T Lindholm… - The Journal of …, 2007 - academic.oup.com
Abstract Context and Objective: In Sweden, from 1985 through 1995, 40 fetuses at risk for
congenital adrenal hyperplasia (CAH) were treated with dexamethasone (DEX) to prevent …

The adrenal cortex and its disorders

WL Miller, CE Flück, DT Breault, BJ Feldman - Sperling Pediatric …, 2021 - Elsevier
The adrenal cortex produces dozens of steroids having varying degrees of glucocorticoid,
mineralocorticoid, and androgenic activity. Cortisol, the principal glucocorticoid, and …

New management strategy of pregnancies at risk of congenital adrenal hyperplasia using fetal sex determination in maternal serum: French cohort of 258 cases (2002 …

V Tardy-Guidollet, R Menassa, JM Costa… - The Journal of …, 2014 - academic.oup.com
Context: Prenatal dexamethasone (DEX) treatment has been proposed since 1984 to
prevent genital virilization in girls with congenital adrenal hyperplasia (CAH). DEX is …

46, XX DSD due to androgen excess in monogenic disorders of steroidogenesis: genetic, biochemical, and clinical features

F Baronio, R Ortolano, S Menabò, A Cassio… - International journal of …, 2019 - mdpi.com
The term 'differences of sex development'(DSD) refers to a group of congenital conditions
that are associated with atypical development of chromosomal, gonadal, or anatomical sex …

Long-term follow-up of prenatally treated children at risk for congenital adrenal hyperplasia: does dexamethasone cause behavioural problems?

T Hirvikoski, A Nordenström, T Lindholm… - European Journal of …, 2008 - academic.oup.com
Objectives To investigate the long-term effects of prenatal treatment of congenital adrenal
hyperplasia (CAH) with emphasis on behavioural problems and temperament. Design A …

Adrenal disease in pregnancy

O Lekarev, MI New - Best Practice & Research Clinical Endocrinology & …, 2011 - Elsevier
Adrenal disorders in pregnancy are relatively rare, yet can lead to significant maternal and
fetal morbidity. Making a diagnosis is challenging as pregnancy may alter the manifestation …

MANAGEMENT OF ENDOCRINE DISEASE: Congenital adrenal hyperplasia due to 21-hydroxylase deficiency: update on the management of adult patients and …

A Bachelot, V Grouthier, C Courtillot… - European journal of …, 2017 - academic.oup.com
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is characterized by
cortisol and in some cases aldosterone deficiency associated with androgen excess. Goals …

Maternal exposure to dexamethasone or cortisol in early pregnancy differentially alters insulin secretion and glucose homeostasis in adult male sheep offspring

MJ De Blasio, M Dodic, AJ Jefferies… - American Journal …, 2007 - journals.physiology.org
An adverse intrauterine environment increases the risk of developing various adult-onset
diseases, whose nature varies with the timing of exposure. Maternal undernutrition in …