Runx2 is essential for osteoblast differentiation and chondrocyte maturation. During
osteoblast differentiation, Runx2 is weakly expressed in uncommitted mesenchymal cells …

Runx2 is a transcription factor that is essential for osteoblast differentiation and chondrocyte
maturation. Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for …

Runx2 is an essential transcription factor for skeletal development. It is expressed in
multipotent mesenchymal cells, osteoblast-lineage cells, and chondrocytes. Runx2 plays a …

Runx2 and Sp7 are essential transcription factors for osteoblast differentiation. However, the
molecular mechanisms responsible for the proliferation of osteoblast progenitors remain …

Background: Osteosarcoma is the most common primary malignant bone tumour,
predominantly affecting children and adolescents. Cancer cell line models are required to …

The scanning model for eukaryotic mRNA translation initiation states that the small
ribosomal subunit, along with initiation factors, binds at the cap structure at the 5′ end of …

Injectable hydrogel systems are important bone substitutes for regeneration because of their
handling properties and the ability to fill irregular defects. Silk–hydroxyapatite composite …

The vicious cycle established between bone-associated tumours and bone resorption is the
central problem with therapeutic strategies against primary bone tumours and bone …

Bromodomain and extra terminal domain (BET) proteins are important epigenetic regulators
facilitating the transcription of genes in chromatin areas linked to acetylated histones. JQ1, a …

Osteoinductive biomaterials are attractive for repairing a variety of bone defects, and
biomimetic strategies are useful toward developing bone scaffolds with such capacity. Here …